VASCULAR AND INTERVENTIONAL RADIOLOGY
|Year : 2015 | Volume
| Issue : 4 | Page : 380-390
|Clinical outcomes of endovascularly managed iatrogenic renal hemorrhages
George Koshy Chiramel1, Shyamkumar Nidugala Keshava1, Vinu Moses1, Nitin Kekre2, V Tamilarasi3, Anthony Devasia2
1 Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India
3 Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India
Click here for correspondence address and email
|Date of Web Publication||12-Nov-2015|
| Abstract|| |
Objective: To evaluate the effectiveness of endovascular management in iatrogenic renal injuries with regard to clinical status on follow-up and requirements for repeat angiography and embolization. Materials and Methods: This retrospective study included patients who were referred for endovascular management of significant hemorrhage following an iatrogenic injury. Data was recorded from the Picture Archiving and Communication system (PACS) and electronic medical records. The site and type of iatrogenic injury, imaging findings, treatment, angiography findings, embolization performed, clinical status on follow-up, and requirement for repeat embolization were recorded. The outcomes were clinical resolution, nephrectomy, or death. Clinical findings were recorded on follow-up visits to the clinic. Statistical analysis was performed using descriptive statistics. Results: Seventy patients were included in this study between January 2000 and June 2012. A bleeding lesion (a pseudoaneurysm or arteriovenous fistula) was detected during the first angiogram in 55 patients (78.6%) and was selectively embolized. Fifteen required a second angiography as there was no clinical improvement and five required a third angiography. Overall, 66 patients (94.3%) showed complete resolution and 4 patients (5.7%) died. Three patients (4.3%) underwent nephrectomy for clinical stabilization even after embolization. There were no major complications. The two minor complications resolved spontaneously. Conclusions: Angiography and embolization is the treatment of choice in iatrogenic renal hemorrhage. Upto 20% of initial angiograms may not reveal the bleed and repeat angiography is required to identify a recurrent or unidentified bleed. The presence of multiple punctate bleeders on angiography suggests an enlarging subcapsular hematoma and requires preoperative embolization and nephrectomy.
Keywords: Bleeding; embolization; endovascular management; iatrogenic renal hemorrhages; iatrogenic renal vascular injuries
|How to cite this article:|
Chiramel GK, Keshava SN, Moses V, Kekre N, Tamilarasi V, Devasia A. Clinical outcomes of endovascularly managed iatrogenic renal hemorrhages. Indian J Radiol Imaging 2015;25:380-90
|How to cite this URL:|
Chiramel GK, Keshava SN, Moses V, Kekre N, Tamilarasi V, Devasia A. Clinical outcomes of endovascularly managed iatrogenic renal hemorrhages. Indian J Radiol Imaging [serial online] 2015 [cited 2020 Oct 29];25:380-90. Available from: https://www.ijri.org/text.asp?2015/25/4/380/169454
| Introduction|| |
Fifty percent of renal injuries are iatrogenic in etiology., and 15% of all invasive procedures, either surgical or percutaneous, would result in a vascular injury.,, Patients develop a significant drop in hematocrit, persistent hematuria, or an enlarging perirenal bleed causing loin pain. Some could develop altered renal function, urinary obstruction, hypertension, or cardiac failure. Also, 70-90% of vascular injuries resolve spontaneously, and treatment is indicated for a massive bleed, deteriorating renal function, or renal hemorrhage which persists for more than 72 h., The treatment of choice is endovascular, with angiography and selective embolization expected to minimize the loss of renal tissue.,,,,,,,,
| Materials and Methods|| |
This was a retrospective study that included patients referred for endovascular management of severe hemorrhage following an invasive renal procedure. Institutional ethics committee clearance was obtained, and informed consent taken from all patients for the procedure. Data was retrieved from the Picture Archiving and Communication System (PACS), patients' charts, and electronic medical records. The information collected included the findings of angiography and embolization, technical details, clinical status, and findings on subsequent angiography, if performed. Technical success of embolization was defined as the complete occlusion of the target vessel with no residual bleed on angiography. Resolution was defined as clinical improvement with a stable hematocrit and no recurrence of bleed for at least 30 days. Adverse outcomes were nephrectomy and death. The clinical status and serum creatinine values were evaluated using the electronic health records of the patients, as they were followed up in the outpatient clinic. Statistical analysis was performed using descriptive statistics to calculate the means, proportions, and percentages.
Protocol followed for management of renal hemorrhage
The clinical algorithm for managing these patients is shown in [Figure 1]. Digital subtraction angiography was performed on an emergency basis in all patients (Multistar DSA; Siemens, Erlangen, Germany). The contrast agent in patients with a normal serum creatinine value was Iohexol (Omnipaque; GE Amersham Health, Princeton, NJ, USA). If the serum creatinine level was between 1.5 and 3 mg%, Iodixanol (Visipaque; GE Amersham) was used. Carbon dioxide was used as the contrast agent in one patient who had a serum creatinine higher than 3.5 mg%. Computed tomography (CT) angiography was not performed routinely prior to endovascular treatment. A contrast-enhanced CT of the abdomen was also not part of the routine protocol, but was performed in a few patients if their condition did not resolve after embolization. An initial aortogram was performed to study the renovascular anatomy, identify anatomic variations, and detect a bleed from an intercostal or lumbar artery. Anteroposterior projections were used as a standard during the initial angiogram. An oblique projection was used if there was a doubt regarding the origin of the vessel leading to the bleeding lesion. Selective renal angiography of the suspected side of bleed was performed with a 4F hydrophilic cobra catheter (Terumo; Target Therapeutics, San Francisco, CA, USA). Additional selective angiography of the adjacent lumbar or lower intercostal arteries was also performed if an intrarenal bleed was not identified. If a bleeding vessel was identified, embolization was performed in the same session. The vessel was superselectively cannulated as close as possible to the site of bleed using a coaxially placed 2.7F microcatheter (Progreat; Terumo, Target Therapeutics, San Francisco, CA, USA). Embolization with coils (0.035″) was performed through the cobra catheter itself in a few cases, if it was placed very close to the site of bleed. The embolization agents used depended on the site and characteristics of the bleeding lesion. Either 0.035″ embolization coils (Cook, Bloomington, IN, USA ) or 0.018″ coils (Fibred microcoils, Target therapeutics, USA) were used. Polyvinyl alcohol particles (Contour; Boston Scientific, Marlborough, MA, USA) or gelfoam were used as adjuvants along with embolization coils in a few cases to reduce the blood flow through the vessel. If an arteriovenous fistula was visualized, n-butyl cyanoacrylate glue (Histoacryl; Bbraun, Tuttlingen, Germany) was the embolization material of choice [Table 1]. The management of these patients and the decisions were based on the clinical status and the clinical management protocol. During emergency angiography, if no obvious cause for the bleeding was identified and the patient remained hemodynamically unstable despite good supportive care, empirical embolization was performed at the iatrogenic trauma. If the patient was hemodynamically stable, supportive care with close monitoring was continued without empirical embolization .
|Figure 1: Protocol followed for the management of iatrogenic renal injuries|
Click here to view
|Table 1: Different types of bleeds and the preferred embolic agent for management|
Click here to view
| Results|| |
Over a period of 12 years, 70 patients (51 males and 19 females) were referred for endovascular management of a severe bleed secondary to an iatrogenic injury during various procedures. There were 18 percutaneous biopsies, 50 percutaneous nephrolithotomies, and 2 surgeries (a surgical renal biopsy and a partial nephrectomy) [Table 2]. These procedures were on the native kidney in 67 patients and on an allograft kidney in 3 patients. The average age was 41 years, the youngest being 7 months and the oldest being 70 years [Table 3]. The results of the angiography procedures and embolization are described as flowcharts [Figure 2]a,[Figure 2]b,[Figure 2]c.
|Figure 2(A-C): (A) Flowchart showing the number of patients, procedures performed, and the outcomes in the first (A), second (B) and third angiography sessions (C)|
Click here to view
|Table 2: The number and type of cases with iatrogenic injury in this study requiring angiography for embolization|
Click here to view
|Table 3: Details of all the patients included in this study who presented with an iatrogenic injury requiring angiography for potential embolization|
Click here to view
The first angiogram revealed an abnormality in 55 patients (78.6%). Embolization could not be performed in two as the segmental branch developed spasm during superselective cannulation. The spasm was persistent and the branch vessel became thrombosed. Both patients showed complete clinical resolution. Embolization was performed in the rest of the 53 patients of which 38 (71.7%) showed clinical resolution. Two patients died immediately after angiography before further treatment could be done. The angiograms in both these patients had shown multiple punctate bleeding vessels overlying the whole affected kidney for which the main renal artery was embolized with polyvinyl alcohol particles to reduce the bleeding. Thirteen patients (24.5%) who did not resolve hemodynamically after the first angiogram underwent a second angiogram the following day. One patient showed no abnormality and resolved spontaneously. Another showed a bleeding capsular artery but could not be selectively cannulated, and the patient expired before further treatment could be initiated. A second embolization procedure was carried out in 11 patients, of which 6 (54.5%) resolved. The condition of the remaining five did not resolve even though nephrectomy was performed in two patients. Also, all five patients underwent a third angiography. In the two post-nephrectomy patients, there were no abnormalities in both patients. One resolved spontaneously, while the other stabilized after empirical embolization of the overlying intercostal and lumbar arteries but expired in a month. Of the other three patients who underwent a third angiogram, one showed no abnormality and recovered completely while another patient developed persistent spasm of the segmental vessel during superselective cannulation, but recovered completely. In the third patient, as the bleeding vessel could not be superselectively cannulated, nephrectomy was done after embolizing the renal artery with Histoacryl glue. This patient recovered completely after nephrectomy. Overall, no abnormality was revealed in the first angiogram in 15 (21.4%) patients. Of these,
recovered with conservative management. One patient underwent a second angiogram which revealed a pseudoaneurysm, and the condition resolved after selective embolization of the vessel. In two patients, empirical embolization with polyvinyl alcohol particles of the segmental branch leading to the site of injury was performed and both recovered completely. Follow-up was in the outpatient clinic. There was no recurrence of bleed on follow-up and no significant rise in serum creatinine levels. Overall, 66 (94.3%) out of 70 patients in this study showed complete resolution. Three (4.3%) underwent nephrectomy and four (5.7%) died. There were two minor complications - a subintimal dissection of a segmental branch and migration of a coil, both of which spontaneously resolved. There were no major complications.
| Discussion|| |
A prior knowledge of the suspected site of renal injury helps to plan the imaging and treatment. The presence of hematuria indicates an intrarenal bleed with calyceal communication. In a patient with no hematuria, the bleed may be either within or outside the kidney. USG and color Doppler can demonstrate the presence of active bleeding into a perinephric hematoma and can be used as follow-up. The use of microcatheters for superselective cannulation and embolization of bleeding vessels helps to minimize the loss of renal tissue.,,,,,,,, A bleed can sometimes be detected on the initial aortogram itself [Figure 3]. It may be visualized as an active extravasation of contrast, a pseudoaneurysm [Figure 4], or an arteriocalyceal or arteriovenous fistula [Figure 5]. Oblique projections and selective renal angiography can help identify the specific arterial branch [Figure 6] and rule out other lesions. Selective cannulation can help detect even subtle lesions. A limited amount of contrast agent is used as the renal function may already be compromised. An iso-osmolar contrast agent is preferred in a patient with raised serum creatinine. Other studies that have evaluated the efficacy of endovascular embolization in iatrogenic renal injuries have included fewer patients and describe only one angiography session, except one study that reports a 67% resolution rate with two angiography sessions., The rate of resolution ranges from 85 to 98%.,, Though none of these studies have described clinical outcomes on long-term follow-up or included patients who required a third angiography, their results were comparable to the 94.3% resolution achieved in our patient population. The most common embolization material used in this study were embolization coils. Occasionally, polyvinyl alcohol particles were used as an adjuvant embolic material to reduce the flow. Histoacryl glue was used in a few cases where an arteriovenous fistula was seen. Other studies have used the same approach to manage renal hemorrhage. Some describe satisfactory results with only Histoacryl glue  or polyvinyl alcohol particles. We have used only the transarterial approach for embolization in this group of patients. Other approaches that have been described are percutaneous ultrasound-guided embolization of a pseudoaneurysm with gelfoam  or embolization coils.
|Figure 3(A-E): (A) Aortogram shows a pseudoaneurysm (arrow) in the lower pole of the left kidney (B) This was confirmed by a selective angiogram of the left renal artery (C) The lower segmental artery was superselectively cannulated with a microcatheter (D) Two 0.018″ embolization coils were deployed (E) Post-embolisation embolization angiogram shows complete occlusion of the branch|
Click here to view
|Figure 4(A-C): (A) Selective angiogram of the left renal artery shows a pseudoaneurysm (arrow) in the lower pole region. The large area seen as a filling defect is the surrounding hematoma (B) Superselective cannulation of this vessel and embolization with Histoacryl glue (C) Post-embolization angiogram shows occlusion of the vessel with no opacification of the pseudoaneurysm|
Click here to view
|Figure 5(A-C): (A) Selective angiogram of the left renal artery shows an arteriovenous fistula in the lower pole region with a prominent draining vein (arrow) (B) Superselective cannulation of the arterial branch which developed spasm and thrombosis (C) Angiogram shows spontaneous resolution of the arteriovenous fistula with no opacification of the draining vein|
Click here to view
|Figure 6(A-C): (A) Left renal angiogram shows a pseudoaneurysm (arrow), but the arterial branch from which this arises is unclear (B) An oblique projection of the angiogram shows the pseudoaneurysm to be arising from a specific interpolar branch (C) Embolization coils deployed within this branch to occlude it|
Click here to view
It was found in this study that up to 20% of the initial angiograms did not show a bleed. This is lower compared to 30% as reported by another study. An angiogram could be negative immediately following an acute bleed. An angiogram could be falsely negative due to the tamponading effect of the hematoma or due to hypotension or transient spasm. Removal of the drainage tube in some cases could remove the tamponade and identify a bleed, thus helping to plan definitive treatment. An arteriocalyceal fistula may sometimes not be visualized if there is a blood clot obstructing the calyx. The source of bleed may sometimes not be identified even on repeated angiograms in a gradually worsening patient and a CT scan could be helpful in this situation. Selective empirical embolization can be helpful in an indeterminate bleed if the site of the renal injury is known, as in iatrogenic renal bleeds. In many situations, even when the bleed was not identified, the patient's condition resolved without further treatment, suggesting a process of spontaneous hemostasis. It is thus important to evaluate and correct for any underlying coagulopathy. Two patients in this study were detected to have hemophilia. Recanalization of a bleeding vessel could be a cause for non-resolution that can persist even after embolization with coils or polyvinyl alcohol particles.
If the angiogram shows multiple punctate bleeding vessels [Figure 7] suggestive of an enlarging subcapsular hematoma, a life-saving nephrectomy should be considered if the patient continues to be hemodynamically unstable. Preoperative embolization of the renal artery with Histoacryl glue may be helpful in an unstable patient while arrangements are being made for a nephrectomy. In the present study, all three patients who underwent nephrectomy were hemodynamically stable for more than a month. Only one patient died after a month in the intensive care unit due to complications related to seizures, aspiration pneumonia, and sepsis. Spasm and thrombosis of the bleeding branch vessel was inadvertently caused in three patients during superselective cannulation that resolved spontaneously [Figure 5]. This is a phenomenon that has also been described in the splanchnic territory.
|Figure 7: Right renal angiogram shows multiple punctate bleeding vessels (arrow) in all regions of the kidney, suggesting the presence of an enlarging subcapsular hematoma|
Click here to view
No major complications have been described in the literature. Minor complications include non-target glue embolization, coil migration, and renal artery occlusion. Renal artery dissection is a previously described complication which resolves spontaneously., Ureteric obstruction due to a migrated coil has also been described. Non-target embolization can lead to post-embolization syndrome, hypertension, and functional impairment of the kidney. None of the patients in this study developed post-embolization syndrome. The two minor complications which had occurred in this study, segmental artery dissection and coil migration [Figure 8], had both resolved spontaneously.
|Figure 8(A and B): (A) Selective angiogram of the right renal artery showing a pseudoaneurysm (arrow) in the lower pole region for which embolization with coils was done (B) Post-embolization angiogram shows non-opacification of the pseudoaneurysm and migration of one of the coils into an adjacent arterial branch (arrow) resulting in non-target embolization|
Click here to view
| Conclusion|| |
Angiography and selective embolization is safe and effective in iatrogenic renal vascular injuries. A second or a third angiogram is beneficial to detect an unidentified or recurrent bleed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Poulakis V, Ferakis N, Becht E, Deliveliotis C, Duex M. Treatment of renal-vascular injury by transcatheter embolization: Immediate and long-term effects on renal function. J Endourol 2006;20:405-9.
Fisher RG, Ben-Menachem Y, Whigham C. Stab wounds of the renal artery branches: Angiographic diagnosis and treatment by embolization. AJR Am J Roentgenol 1989;152:1231-5.
Orons PD, Zajko AB. Angiography and interventional aspects of renal transplantation. Radiol Clin North Am 1995;33:461-71.
Hübsch PJ, Mostbeck G, Barton PP, Gritzmann N, Fruehwald FX, Schurawitzki H, et al
. Evaluation of arteriovenous fistulas and pseudoaneurysms in renal allografts following percutaneous needle biopsy. Color-coded Doppler sonography versus duplex Doppler sonography. J Ultrasound Med 1990;9:95-100.
Sennet CA, Messersmith RN, Yousefzadeh DK, Thistlethwaite JR Jr. Percapsular and percutaneous embolization of renal transplant pseudoaneurysm and AV fistula: Case report. Cardiovasc Intervent Radiol 1989;12:270-3.
Maleux G, Messiaen T, Stockx L, Vanrenterghem Y, Wilms G. Transcatheter embolization of biopsy-related vascular injuries in renal allografts. Long-term technical, clinical and biochemical results. Acta Radiol 2003;44:13-7.
Huppert PE, Duda SH, Erley CM, Roth M, Lauchart W, Dietz K, et al
. Embolization of renal vascular lesions: Clinical experience with microcoils and tracker catheters. Cardiovasc Intervent Radiol 1993;16:361-7.
Dorffner R, Thurnher S, Prokesch R, Bankier A, Turetschek K, Schmidt A, et al
. Embolization of iatrogenic vascular injuries of renal transplants: Immediate and follow-up results. Cardiovasc Intervent Radiol 1998;21:129-34.
Somani BK, Nabi G, Thorpe P, McClinton S. Endovascular control of haemorrhagic urological emergencies: An observational study. BMC Urol 2006;6:27.
Mavili E, Dönmez H, Ozcan N, Sipahioğlu M, Demirtaş A. Transarterial embolization for renal arterial bleeding. Diagn Interv Radiol 2009;15:143-7.
Hellström PA, Mehik A, Talja MT, Siniluoto TM, Perala JM, Leinonen SS. Spontaneous subcapsular or perirenal haemorrhage caused by renal tumours. A urological emergency. Scand J Urol Nephrol 1999;33:17-23.
Bookstein JJ, Goldstein HM. Successful management of postbiopsy arteriovenous fistula with selective arterial embolization. Radiology 1973;109:535-6.
Vignali C, Lonzi S, Bargellini I, Cioni R, Petruzzi P, Caramella D, et al
. Vascular injuries after percutaneous renal procedures: Treatment by transcatheter embolization. Eur Radiol 2004;14:723-9.
Yeniyol CO, Zeyrek N, Parildar M, Selek E, Taşli F, Memiş A. Life-threatening hematuria in a patient with renal angiomyolipoma and selective renal embolization prior to nephrectomy. Int Urol Nephrol 2002;34:185-8.
Lovaria A, Nicolini A, Meregaglia D, Saccheri S, Rivolta R, Rampoldi A, et al
. Interventional radiology in the treatment of urological vascular complications. Ann Urol (Paris) 1999;33:156-67.
Hom D, Eiley D, Lumerman JH, Siegel DN, Goldfischer ER, Smith AD. Complete renal embolization as an alternative to nephrectomy. J Urol 1999;161:24-7.
Lupattelli T, Garaci FG, Manenti G, Belli AM, Simonetti G. Giant high-flow renal arteriovenous fistula treated by percutaneous embolization. Urology 2003;61:837.
Huber J, Pahernik S, Hallscheidt P, Sommer CM, Wagener N, Hatiboglu G, et al
. Selective transarterial embolization for posttraumatic renal hemorrhage: A second try is worthwhile. J Urol 2011;185:1751-5.
Jain V, Ganpule A, Vyas J, Muthu V, Sabnis RB, Rajapurkar MM, et al
. Management of non-neoplastic renal hemorrhage by transarterial embolization. Urology 2009;74:522-6.
Perini S, Gordon RL, LaBerge JM, Kerlan RK Jr, Wilson MW, Feng S, et al
. Transcatheter embolization of biopsy-related vascular injury in the transplant kidney: Immediate and long-term outcome. J Vasc Interv Radiol 1998;9:1011-9.
Sam K, Gahide G, Soulez G, Giroux MF, Oliva VL, Perreault P, et al
. Percutaneous embolization of iatrogenic arterial kidney injuries: Safety, efficacy, and impact on blood pressure and renal function. J Vasc Interv Radiol 2011;22:1563-8.
Cantasdemir M, Adaletli I, Cebi D, Kantarci F, Selcuk ND, Numan F. Emergency endovascular embolization of traumatic intrarenal arterial pseudoaneurysms with N-butyl cyanoacrylate. Clin Radiol 2003;58:560-5.
Davidson GS, Terbrugge KG. Histologic long-term follow-up after embolization with polyvinyl alcohol particles. AJNR Am J Neuroradiol 1995;16(Suppl):843-6.
Sakr MA, Desouki SE, Hegab SE. Direct percutaneous embolization of renal pseudoaneurysm. J Endourol 2009;23:875-8.
Cowan NC, Traill ZC, Phillips AJ, Gleeson FV. Direct percutaneous transrenal embolization for renal artery injury following percutaneous nephrostomy. Br J Radiol 1998;71:1199-201.
Phadke RV, Sawlani V, Rastogi H, Kumar S, Roy S, Baijal SS, et al
. Iatrogenic renal vascular injuries and their radiological management. Clin Radiol 1997;52:119-23.
Axelrod DJ, Freeman H, Pukin L, Guller J, Mitty HA. Guide wire perforation leading to fatal perirenal hemorrhage from transcortical collaterals after renal artery stent placement. J Vasc Interv Radiol 2004;15:985-7.
Cynamon J, Atar E, Steiner A, Hoppenfeld BM, Jagust MB, Rosado M, et al
. Catheter-induced vasospasm in the treatment of acute lower gastrointestinal bleeding. J Vasc Interv Radiol 2003;14:211-6.
Corr P, Hacking G. Embolization in traumatic intrarenal vascular injuries. Clin Radiol 1991;43:262-4.
Rajesparan K, Partridge W, Taha N, Samman R, Aldin Z. Early migration and ureteric obstruction of an embolisation coil used to treat massive haemorrhage following percutaneous nephrolithotomy. Cardiovasc Intervent Radiol 2011;34:868-72.
George Koshy Chiramel
Department of Radiology, Christian Medical College, Vellore - 632 004, Tamil Nadu
Source of Support: None, Conflict of Interest: None
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8]
[Table 1], [Table 2], [Table 3]
| Article Access Statistics|
| Viewed||2669 |
| Printed||36 |
| Emailed||0 |
| PDF Downloaded||227 |
| Comments ||[Add] |