|Year : 2009 | Volume
| Issue : 1 | Page : 7-15
|Three-dimensional imaging for hepatobiliary and pancreatic diseases: Emphasis on clinical utility
Soo Jin Kim1, Byung Ihn Choi2, Se Hyung Kim1, Jae Young Lee1
1 Department of Radiology and the Institute of Radiation Medicine, Seoul National University Hospital, Seoul, 110-744, Korea
2 Department of Radiology and the Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea
Click here for correspondence address and email
| Abstract|| |
Three-dimensional (3D) imaging allows disease processes and anatomy to be better understood, both by radiologists as well as physicians and surgeons. 3D imaging can be performed with USG, CT scan and MRI, using different modes or rendering that include surface-shaded display, volume-based rendering, multiplanar imaging, etc. All these techniques are used variably depending on the indications.
Keywords: three-dimensional image, ultrasonography, CT, MRI
|How to cite this article:|
Kim SJ, Choi BI, Kim SH, Lee JY. Three-dimensional imaging for hepatobiliary and pancreatic diseases: Emphasis on clinical utility. Indian J Radiol Imaging 2009;19:7-15
Three-dimensional (3D) imaging has become a popular modality because of its ability to provide 3D views of the patient's anatomy. It also does not have many of the inherent shortcomings of two-dimensional (2D) imaging. Two-dimensional images make interpretation more difficult by forcing the reader to restructure the 2D images mentally in order to appreciate the true form of the disease or organ. Three-dimensional images, on the other hand, provide easier-to-understand information, while being more efficient, accurate, objective, and reproducible. Three-dimensional imaging is more photorealistic due to advanced rendering; allows any arbitrary plane to be obtained, which was not previously possible with 2D USG techniques; and increases patient throughout by offline rendering.
|How to cite this URL:|
Kim SJ, Choi BI, Kim SH, Lee JY. Three-dimensional imaging for hepatobiliary and pancreatic diseases: Emphasis on clinical utility. Indian J Radiol Imaging [serial online] 2009 [cited 2020 Nov 29];19:7-15. Available from: https://www.ijri.org/text.asp?2009/19/1/7/45336
In this review, the clinical utility of 3D imaging with USG, CT scan, and MRI in hepatobiliary diseases will be discussed.
| Three-dimensional USG|| |
The selection of the rendering technique used very often determines which information is transmitted to the operator by the 3D USG image display.  There are many techniques for displaying 3D images; they are divided into three classes: surface rendering, multiplanar viewing, and volume rendering.  The choice of the best rendering technique is generally determined by the clinical application.
1. Surface-based rendering: The most commonly used 3D display technique is based on the visualization of surfaces of structures or organs. This technique can be performed manually, with the operator determining the boundaries of the structures, or by automated techniques.  After the tissues or structures have been classified, a surface-rendering algorithm shades and illuminates the surface representation, at times adding depth cues, so that topography and 3D geometry can be more easily comprehended. An example of 3D surface rendering is shown in [Figure 1], which demonstrates a small polyp in a distended gallbladder. The operators may view the anatomy from different perspectives using either automatic rotation or user-controlled motion.
2. Multiplanar viewing: In multiplanar viewing, a 3D voxelbased image must first be reconstructed and then be easily accessible by the display algorithm. Computer user-interface tools allow a selection of planes from the volume, including the oblique plane, to be viewed as reformatted 2D images. Not only do these planes appear similar to those obtained by conventional 2D USG imaging with proper interpolation, but the technique also provides a display of an arbitrary plane that was not possible using conventional 2D USG technique.  Three perpendicular planes are displayed on the screen simultaneously, with screen cues as to their relative orientation and intersections, allowing the operator to properly orient the reformatted images [Figure 2]. Several commercially available 3D USG systems already use this technique.
3. Volume-based rendering: The most widely used volume-based rendering approach is the ray-casting technique,  which projects a 2D array of rays on the 3D image. Another common approach is to form a maximum intensity projection (MIP) image by displaying only the voxels with the maximum intensity along each ray.  Similarly, a minimum intensity projection (minIP) image can be also reconstructed when only the voxels with the minimum intensity along each ray are displayed.
Inversion mode is a new post-processing tool that uses a rendering algorithm for the 3D analysis of fluid-filled structures  and transforms echolucent structures into solid voxels. Thus, anechoic structures, such as the lumen of the great vessels, bile duct, and gallbladder, appear echogenic on the rendered image, whereas structures that are normally echogenic prior to gray-scale inversion (e.g. bones) become anechoic. Examples are shown in [Figure 3].
Application in the hepatobiliary system
Compared with CT scan or MRI, USG has an advantage in that the scanning plane can be selected more freely than with the other modalities. However, in clinical practice, this is sometimes not possible. For instance, the true coronal plane of the liver is hard to obtain because a part of the liver is sheltered behind the lower ribs. Three-dimensional USG can display information in a manner that has not previously been possible with conventional techniques.  Three-dimensional volumetric measurements, including gallbladder measurements to assess gallbladder function, have been made more accurate by recent developments in 3D USG. , This improved accuracy, especially for organs with an irregular shape such as the gallbladder, also reduces the variability in serial measurements, thus standardizing sonographic procedures. Recently, Kim et al , have reported that 3D USG of the gallbladder is clinically feasible and more useful than oral cholecystography or 2D USG alone.  Their results showed an excellent correlation between gallbladder ejection fractions measured using 3D USG and the grades of oral cholecystograms. The results indicated the superiority of 3D USG over oral cholecystography for evaluating patients with gallbladder dysfunction and, moreover, demonstrated the clinical usefulness of volumetric analysis by 3D USG for gallbladder evaluation. Volumetric assessment of solid tumor burden is also important in the field of oncology because 3D measurement of tumor volumes gives a more accurate assessment of tumor burden than do traditional unidimensional and bidimensional measurements. This is also true for the monitoring of tumor burden after local ablation treatments such as percutaneous ethanol injection or radiofrequency ablation. Indeed, several reports have proved that volumetric measurement of the tumor with 3D USG is a more accurate tool than traditional 2D measurement.  In addition, 3D USG permits three-dimensional visualization of the tumor with its adjacent vessels, imaging of gallbladder pathology and of the structures of the biliary duct, and 4D USG helps guide procedures like biopsies and ablations. ,
| Three-dimensional CT|| |
For the evaluation of suspected hepatic and biliary pathology, CT scan has been the most widely used modality. Recently, multidetector CT scan (MDCT) has been shown to be quite useful, especially for hepatic volume acquisitions, by combining short scan times and narrow collimation with the ability to obtain multiphasic data. These features result in improved lesion detection and characterization. With advances in computer software, 3D applications for hepatic image analyses and displays have been made possible and practical. Kamel et al , have discussed the specific types of hepatic and biliary pathology in which MDCT has a significant diagnostic impact. 
| Preoperative assessment of complex anatomy|| |
Choi et al , performed a study to evaluate the usefulness of multiplanar reconstruction (MPR) images in the assessment of the biliary tree of patients with bile duct cancer. MPRs provide intuitive images and a roadmap for surgeons, displaying the entire length of the bile duct and showing ductal thickening and intraductal masses. According to their results, they could not obtain significantly improved diagnostic performance by adding MPR images to the standard axial images in complex structures like the hepatic hilum. However, they insisted that although MPRs do not increase diagnostic performance in patients with bile duct cancer, they are still valuable in planning therapeutic options and giving confidence to surgical decisions, as well as in allowing a second way of looking at the tumor. MPRs are expected to be very helpful for radiologists with limited experience in hepatobiliary imaging by providing easier-to-read images and views from different angles. Furthermore, one study has shown that when assessing vascular involvement and tumor resectability, higher interobserver agreement was seen in the group that viewed combined axial and MPR images than in the group that viewed only the axial images  [Figure 4].
CT cholangiography or portography using minIP, MIP, and volume rendering images can be useful in the preoperative evaluation of the tumor extent in hilar cholangiocarcinoma [Figure 5].
Recently, Uchida et al , described how CT image fusion with 3D reconstructions is used to depict the anatomic structures of the hepatic hilum in detail in the presence of hepatobiliary abnormalities. They illustrated the anatomic features of the hepatic hilum in 3D detail, using a fusion of CT angiographic and CT cholangiographic images; this allows a one-step, comprehensive, noninvasive evaluation of the hepatic hilum. They insisted that high-resolution 3D fusion images will be extremely useful for evaluation of the hepatic hilar anatomy, which is essential for preoperative planning of hepatic and bile duct resection and for liver transplantation. 
In pancreatic cancer, 3D images allow accurate preoperative local staging, as well as assessment of local resectability, because thin-slice MPR imaging exactly depicts the grade of circumferential involvement and improves the assessment of vascular invasion.  With angiographic datasets, displays of the local venous and arterial anatomy can be created, which can provide exact spatial information, show the relation with adjacent structures, and provide other accurate information necessary for surgical planning.  Pancreaticography-type images can also be created through advanced rendering [Figure 6].
In the detection of pancreatic carcinoma, MPR images are equivalent to axial images. Curved MPR images improve the depiction of the main pancreatic duct and increase diagnostic performance as compared to axial images alone. Diagnostic performance was significantly improved when both axial and MPR images were used  [Figure 7].
Volume-rendered cholangiopancreatography (VRCP) is a 3D image created by using a postprocessing computer algorithm from intravenous contrast-enhanced abdominal CT datasets, without the use of a biliary contrast agent. Johnson et al . reported that VRCP in the setting of biliary obstruction due to pancreatic cancer provided valuable 3D information about the intra- and extrahepatic biliary tree, especially with regard to the location and length of the obstruction and the relationship of the intrahepatic ducts to liver metastases; this information was helpful in planning biliary drainage. 
| Preoperative local staging of gallbladder cancer|| |
Kim et al . reported the diagnostic performance of axial-only images and of combined axial and MPR datasets for differentiating ≤ T2 from ≥ T3 tumors; the combined axial and MPR datasets showed statistically significant greater accuracy ( P = 0. 0412).  They also revealed that combining MPR images with axial images improved the overall accuracy of T-staging of MDCT with axial images (from 71.7% to 84.9%; P = 0.0233), especially due to the reduction in partial volume effects, which may be problematic in areas where the gallbladder axis is tangential to the scanning plane [Figure 8]. Furthermore, since the oblique coronal surgical plane can be simulated on MPR, the MPR images may be helpful in surgical planning. 
| Assessment of anomalous pancreaticobiliary ductal junction|| |
Using high-resolution multiplanar reconstruction MDCT images it is possible to ascertain where the pancreatic and biliary ducts join, allowing a diagnosis of anomalous pancreaticobiliary ductal junction.  The entire course of the common channel itself is not always well seen on axial CT because, in many cases, the channel courses through an area of reduced enhancement, between the pancreatic head and the duodenum;, in some cases, the entire course of the common channel is difficult to see on a single-slice multiplanar reconstruction image; and, often, the common channel is tortuous. In addition, as Sugiyama et al . reported, the length of the common channel on CT is not always fully consistent with that found on ERCP.  However, MDCT can usually determine the relationship between the confluence of the pancreatic and biliary ducts and the pancreatic parenchyma in most cases. These favorable results may be because of the following two reasons: first, isotropic or nearly isotropic imaging, using axial reconstruction images with a 0.5-mm or 1-mm slice thickness at 0.5-mm intervals over a 260-mm field of view provides sufficiently high resolution in the z-axis for the evaluation of the pancreatic and biliary ducts;  second, because of oblique passes of the common bile duct through the pancreatic head and the second part of the duodenum.
| Liver transplantation: Preoperative evaluation of vascular anatomy|| |
A comprehensive vascular roadmap facilitates detailed surgical planning and reduces the postoperative complication rate in both, the donor and the recipient.  MDCT enables exquisite anatomical detail to be obtained as a result of improvements in spatial and temporal resolution. , Workstation manipulation of the datas et al lows those images to be created that a transplant surgeon can readily understand. [Figure 9] and [Figure 10].
| Detection of complications and guidance of procedure|| |
The incidence of biliary complications has ranged from 11 to 25%. They are a major cause of morbidity following orthotopic liver transplantation and affect graft survival, the duration of hospital stay, recovery, and overall cost of care. The most common complications are biliary leaks, strictures, and stones.  Portal vein stenosis or thrombosis occuring during the early posttransplantation period can be devastating, resulting in loss of the graft.  Therefore, knowledge of these complications and early detection are important. The development of therapeutic endoscopic and percutaneous radiologic methods has made it possible to manage these complications in a less invasive manner. MPR images can be helpful in determining these therapeutic approaches [Figure 11],[Figure 12],[Figure 13],[Figure 14].
| Three-dimensional MRI|| |
Liver transplantation: Preoperative evaluation of vascular and bile duct anatomy
MRI is a useful alternative to CT and has the advantage of being radiation free. Technological breakthroughs in MRI development, such as advances in gradient strength and surface coil sensitivity and the introduction of parallel imaging, have led to the availability of high-resolution MRI with short acquisition times. Several studies have shown that both CTA and MRI angiography (MRA) produce sufficient information of the hepatic vascular anatomy in living liver donor candidates  [Figure 15].
Many studies have shown that MRI cholangiography (MRC), using T2W TSE or HASTE sequences, can clearly depict the biliary anatomy, but cannot show all biliary anomalies due to the limited resolution and 2D character of these sequences.  However, even though 3D MRC may provide superior image quality as compared to 2D MRC for the evaluation of the extent of disease in malignant biliary obstructions, there has been no statistically significant difference in accuracy  [Figure 16] and [Figure 17].
Depiction of the communication between pancreatic intraductal papillary mucinous neoplasm (IPMN) and pancreatic duct
In a recent publication, Sahani et al ,  have shown that MDCT combined with 2D curved reformation can provide imaging details similar to MRCP, in patients with IPMN and can show communication of the branch duct-type IPMN with the main pancreatic duct. According to Song et al , the diagnostic confidence with MRCP for evaluating the ductal communication of the cystic lesions in 25 patients (25/53, 47%) [Figure 18] with available 2D curved reformation images was higher than with MDCT and MPR images. So, even though MDCT using various postprocessing techniques provides detailed information on cystic structures  , MRCP is still usually better than thin-section CT scans. 
| Summary|| |
There is more to three-dimensional imaging than just pretty pictures. 3D imaging's ability to redefine diagnostic confidence in three-dimensional planes has made it possible to solve many clinical problems. The advantages of 3D imaging are that it allows real-time multiplanar imaging and global depiction of 3D anatomy, there is less operator dependency, and it is more objective. Three-dimensional imaging is especially helpful in hepatobiliary and pancreatic disease evaluation because it is of help in understanding the spatial anatomy and pathology, in enhancing clinical efficiency by providing intuitive images, and in increasing the confidence of accurate targeting in interventions.
| Acknowledgement|| |
The authors thank Hyun Joo Kim, the application specialist of GE healthcare for providing 3D reconstruction.
| References|| |
|1.||Kim SH, Choi BI. Three-dimensional (3D) and four-dimensional (4D) ultrasound: Techniques and abdominal applications. J Med Ultrasound 2007;15:228-42 |
|2.||Fenster A, Downey DB. Three-dimensional ultrasound imaging. Annu Rev Biomed Eng 2000;2:457-75. [PUBMED] [FULLTEXT]|
|3.||Lobregt S, Viergever MA. A discrete dynamic contour model. IEEE Trans Med Imaging 1995;14:12-24. [PUBMED] [FULLTEXT]|
|4.||Fenster A Downey DB. 3D Ultrasound imaging: A review. IEEE Eng Med Biol 1996;15:41-51. |
|5.||Levoy M. Volume rendering: A hybrid ray tracer for rendering polypon and volume data. IEEE Comput Graph Appl 1990;10:33-40 |
|6.||Lee W, Gonηalves LF, Espinoza J, Romero R. Inversion mode: A new volume analysis tool for 3-dimensional ultrasonography. J Ultrasound Med 2005;24:201-7. |
|7.||Kim AY, Choi BI, Lee JY, Kim KW, Han JK. Functional analysis of gallbladder using three-dimensional ultrasound: Preliminary results. Ultrasound Med Biol 2002;28:581-8. [PUBMED] [FULLTEXT]|
|8.||Kim SH, Lee JM, Han JK, Brandl H, Choi BI. Volumetric contrast imaging in bile duct sonography: technology and early clinical experience. AJR Am J Roentgenol 2004;183:1602-4 [PUBMED] [FULLTEXT]|
|9.||Park SH, Choi BI, Han JK, Yoon CJ, Lee JW, Kim SS, et al . Volumetric tumor measurement using three-dimensional ultrasound: In vitro phantom study on measurement accuracy under various scanning conditions. Ultrasound Med Biol 2004;30:27-34. [PUBMED] [FULLTEXT]|
|10.||Tanaka S, Kitamura T, Fujita M, Nakanishi K, Okuda S. Color Doppler flow imaging of liver tumors. AJR Am J Roentgenol 1990;154:509-14. [PUBMED] [FULLTEXT]|
|11.||Kamel IR, Liapi E, Fishman EK. Liver and biliary system: Evaluation by multidetector CT. Radiol Clin North Am 2005;43:977-97, vii. [PUBMED] [FULLTEXT]|
|12.||Choi JY, Lee JM, Lee JY, Kim SH, Lee MW, Han JK, et al . Assessment of hilar and extrahepatic bile duct cancer using multidetector CT: Value of adding multiplanar reformations to standard axial images. Eur Radiol 2007;17:3130-8. [PUBMED] [FULLTEXT]|
|13.||Uchida M, Ishibashi M, Sakoda J, Azuma S, Nagata S, Hayabuchi N. CT image fusion for 3D depiction of anatomic abnormalities of the hepatic hilum. AJR Am J Roentgenol 2007;189:W184-91. [PUBMED] [FULLTEXT]|
|14.||Brugel M, Link TM, Rummeny EJ, Lange P, Theisen J, Dobritz M. Assessment of vascular invasion in pancreatic head cancer with multislice spiral CT: Value of multiplanar reconstructions. Eur Radiol 2004;14:1188-95. |
|15.||Brennan DD, Zamboni GA, Raptopoulos VD, Kruskal JB. Comprehensive preoperative assessment of pancreatic adenocarcinoma with 64-section volumetric CT. Radiographics 2007;27:1653-66. [PUBMED] [FULLTEXT]|
|16.||Fukushima H, Itoh S, Takada A, Mori Y, Suzuki K, Sawaki A, et al . Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma. Eur Radiol 2006;16:1709-18. [PUBMED] [FULLTEXT]|
|17.||Johnson PT, Heath DG, Hofmann LV, Horton KM, Fishman EK. Multidetector-row computed tomography with three-dimensional volume rendering of pancreatic cancer: A complete preoperative staging tool using computed tomography angiography and volume-rendered cholangiopancreatography. J Comput Assist Tomogr 2003;27:347-53. [PUBMED] [FULLTEXT]|
|18.||Kim SJ, Lee JM, Lee JY, Choi JY, Kim SH, Han JK, et al . Accuracy of preoperative T-staging of gallbladder carcinoma using MDCT. AJR Am J Roentgenol 2008;190:1-7. |
|19.||Itoh S, Fukushima H, Takada A, Kojir S, Hiroko S, Takeo I. Assessment of anomalous pancreaticobiliary ductal junction with high-resolution multiplanar reformatted images in MDCT. AJR Am J Roentgenol 2006;187:668-75 |
|20.||Sugiyama M, Haradome H, Takahara T, Abe N, Tokuhara M, Masaki T, et al . Anomalous pancreaticobiliary junction shown on multidetector CT. AJR Am J Roentgenol 2003;180:173-5. [PUBMED] [FULLTEXT]|
|21.||Itoh S, Ikeda M, Ota T, Satake H, Takai K, Ishigaki T. Assessment of the pancreatic and intrapancreatic bile ducts using 0.5-mm collimation and multiplanar reformatted images in multislice CT. Eur Radiol 2003;13:277-85. |
|22.||Bassignani MJ, Fulcher AS, Szucs RA, Chong WK, Prasad UR, Marcos A. Use of imaging for living donor liver transplantation. Radiographics 2001;21:39-52. [PUBMED] [FULLTEXT]|
|23.||Low G, Wiebe E, Walji AH, Bigam DL. Imaging evaluation of potential donors in living-donor liver transplantation. Clin Radiol 2008;63:136-45. [PUBMED] [FULLTEXT]|
|24.||Lee SS, Kim TK, Byun JH, Ha HK, Kim PN, Kim AY, et al . Hepatic arteries in potential donors for living related liver transplantation: Evaluation with multi-detector row CT angiography. Radiology 2003;227:391-9. [PUBMED] [FULLTEXT]|
|25.||Scanga AE, Kowdley KV. Management of biliary complications following orthotopic liver transplantation. Curr Gastroenterol Rep 2007;9:31-8. [PUBMED] |
|26.||Ko GY, Sung KB, Yoon HK, Lee S. Early posttransplantation portal vein stenosis following living donor liver transplantation: Percutaneous transhepatic primary stent placement. Liver Transpl 2007;13:530-6. [PUBMED] [FULLTEXT]|
|27.||Dohke M, Watanabe Y, Okumura A, Amoh Y, Oda K, Ishimori T, et al . Anomalies and anatomic variants of the biliary tree revealed by MR cholangiopancreatography. AJR Am J Roentgenol 1999;173:1251-4. [PUBMED] [FULLTEXT]|
|28.||Choi JY, Kim MJ, Lee JM, Lee JY, Kim SH, Kim KW, et al . Magnetic resonance cholangiography: Comparison of two- and three-dimensional sequences for assessment of malignant biliary obstruction. Eur Radiol 2008;18:78-86. [PUBMED] [FULLTEXT]|
|29.||Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF. Intraductal papillary mucinous neoplasm of pancreas: Multi-detector row CT with 2D curved reformations--correlation with MRCP. Radiology 2006;238:560-9. [PUBMED] [FULLTEXT]|
|30.||Foley WD, Kerimoglu U. Abdominal MDCT: Liver, pancreas, and biliary tract. Semin Ultrasound CT MR 2004;25:122-44. [PUBMED] |
|31.||Song SJ, Lee JM, Kim YJ, Kim SH, Lee JY, Han JK, et al . Differentiation of intraductal papillary mucinous neoplasms from other pancreatic cystic masses: Comparison of multirow-detector CT and MR imaging using ROC analysis. J Magn Reson Imaging 2007;26:86-93. [PUBMED] [FULLTEXT]|
Byung Ihn Choi
Department of Radiology and the Institute of Radiation Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744
Source of Support: None, Conflict of Interest: None
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10], [Figure 11], [Figure 12], [Figure 13], [Figure 14], [Figure 15], [Figure 16], [Figure 17], [Figure 18]
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