Indian Journal of Radiology Indian Journal of Radiology  

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Year : 2002  |  Volume : 12  |  Issue : 2  |  Page : 281-284
Multiple and single fraction palliative radiotherapy in bone secondaries a prospective study

Department of Radiotherapy, Medical College, 88, College Street, Calcutta-700073, West Bengal, India

Correspondence Address:
S K Sarkar
80/IE, Kanukilia Road, Calcutta-700029, West Bengal
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Source of Support: None, Conflict of Interest: None

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Objective: This prospective study was done to compare the role of the multi fraction (MF) and single fraction (SF) radiotherapy in the management of bone secondaries as regards potency for pain relief and resultant early toxicities. Materials and Methods: Seventy three out of eight five patients with bone metastases, who fulfilled the inclusion criteria were randomly divided into two groups to be treated by External radiation either by 3000 cGy over 2 weeks in 10 Fractions i.e. multiple fraction (MF) or by 8000 cGy in single fraction (SF). Pre and Post radiation pain relief potential and early toxicities due to the treatment were compared. Results: No significant difference (P>0.50) was observed as regards pain relief which was 84% in Gr-I (MF) and 76% in Gr - II (SF). Similarly incidence of complete pain relief, (42% VS - 35%) no response (16% VS 24%) and early toxicities also show marginal difference. Conclusion: Though both the radiation schedules resulted in considerable reduction of Bone pain in majority of the patients, no significant difference was observed as regards pain relief and early toxicities.

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