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 Indian J Med Microbiol  
 

Figure 6 (A-F): Cerebro-tendinous xanthomatosis – A 23-year-old wheel-chair bound male with multiple subcutaneous swellings and mental retardation. (A) Clinical image of the right lower limb shows subcutaneous swelling – tendon xanthomas. (B) Axial T2WI reveals trilaminar appearance in the cerebellar hemisphere; hyperintensity in the core of the dentate nuclei; surrounding hypointensity suggestive of calcification and cerebellar white matter hyperintensity (white arrows). (C) and (D) images show subtle signal changes along the Corticospinal tracts (white arrows) and centrum semiovale. (E) SWI shows intense blooming of the dentate and adjacent white matter (white arrows) (F) MRS at TE 135 ms shows inverted lactate peak from the cerebellar white matter (white arrow) and decreased NAA peak

Figure 6 (A-F): Cerebro-tendinous xanthomatosis – A 23-year-old wheel-chair bound male with multiple subcutaneous swellings and mental retardation. (A) Clinical image of the right lower limb shows subcutaneous swelling – tendon xanthomas. (B) Axial T2WI reveals trilaminar appearance in the cerebellar hemisphere; hyperintensity in the core of the dentate nuclei; surrounding hypointensity suggestive of calcification and cerebellar white matter hyperintensity <i>(white arrows)</i>. (C) and (D) images show subtle signal changes along the Corticospinal tracts <i>(white arrows)</i> and centrum semiovale. (E) SWI shows intense blooming of the dentate and adjacent white matter <i>(white arrows)</i> (F) MRS at TE 135 ms shows inverted lactate peak from the cerebellar white matter <i>(white arrow)</i> and decreased NAA peak