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 Indian J Med Microbiol  
 

Figure 3 (A-C): Canavan's disease – An 8-month-old girl presented with hypotonia, cortical blindness, and macrocephaly since 3 months of age. (A) Axial T2WI shows extensive hyperintense signal changes in the supratentorial white matter with involvement of the subcortical U-fibres. Patchy signal change is also noted in the globi pallidi (white arrows) and anterolateral thalami bilaterally. (B) Coronal T2WI shows similar signal changes with involvement of the dentate hilus bilaterally (white arrows). (C) MRS at TE 135 ms from the basal ganglia shows large NAA peak at 2.02 ppm

Figure 3 (A-C): Canavan's disease – An 8-month-old girl presented with hypotonia, cortical blindness, and macrocephaly since 3 months of age. (A) Axial T2WI shows extensive hyperintense signal changes in the supratentorial white matter with involvement of the subcortical U-fibres. Patchy signal change is also noted in the globi pallidi <i>(white arrows)</i> and anterolateral thalami bilaterally. (B) Coronal T2WI shows similar signal changes with involvement of the dentate hilus bilaterally <i>(white arrows)</i>. (C) MRS at TE 135 ms from the basal ganglia shows large NAA peak at 2.02 ppm