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 Indian J Med Microbiol  
 

Figure 2 (A-E): Alexander's disease – A 3-year-old boy presented with progressive behavioral disturbances with hypertronia and abnormal gait for the past 1 year. (A) Axial T2WI shows hyperintensity in the cerebellar white matter and dentate nuclei (white arrowhead); (B) extensive supratentorial white matter hyperintensities are noted, with frontal predominance and involvement of subcortical white matter. Capping is noted adjacent to the frontal horns bilaterally, hypointense on T2 (B) (white arrow), and hyperintense on T1WI (C). Bilateral striatal atrophy with altered signal intensity noted with associated dilatation of the lateral ventricles. (D and E) Axial T1 postcontrast reveals enhancement of the dentate nucleus and peridentate cerebellar white matter (white arrows) as well as the periventricular rim (white arrowheads)

Figure 2 (A-E): Alexander's disease – A 3-year-old boy presented with progressive behavioral disturbances with hypertronia and abnormal gait for the past 1 year. (A) Axial T2WI shows hyperintensity in the cerebellar white matter and dentate nuclei (white arrowhead); (B) extensive supratentorial white matter hyperintensities are noted, with frontal predominance and involvement of subcortical white matter. Capping is noted adjacent to the frontal horns bilaterally, hypointense on T2 (B) <i>(white arrow)</i>, and hyperintense on T1WI (C). Bilateral striatal atrophy with altered signal intensity noted with associated dilatation of the lateral ventricles. (D and E) Axial T1 postcontrast reveals enhancement of the dentate nucleus and peridentate cerebellar white matter <i>(white arrows)</i> as well as the periventricular rim <i>(white arrowheads)</i>