Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

NEUROIMAGING
Year
: 2019  |  Volume : 29  |  Issue : 4  |  Page : 350--355

Neonatal hypoxic encephalopathy: Correlation between post-cooling brain MRI findings and 2 years neurodevelopmental outcome


Emilia Rosniza Mohammed Rusli1, Juriza Ismail2, Wong Saw Wei2, Shareena Ishak2, Rohana Jaafar2, Faizah Mohd Zaki1 
1 Department of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, Cheras, 56000 Kuala Lumpur, Malaysia
2 Department of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, Cheras, 56000 Kuala Lumpur, Malaysia

Correspondence Address:
Dr. Faizah Mohd Zaki
Department of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur
Malaysia

Objective: This study aims to evaluate the magnetic resonance imaging (MRI) brain patterns among hypoxic-ischemic encephalopathy (HIE) babies who underwent post-cooling MRI brain as well as to correlate the post-cooling brain scoring with patient's neurodevelopmental outcome at 2 years. Subjects and Methods: It was a retrospective cross sectional study carried out at a tertiary university hospital. Record of patients diagnosed with neonatal HIE from 2007 until 2016 who completed 72 h of cooling therapy and had MRI brain within 2 weeks of life were included in this study. A new scoring system by Trivedi et al. that emphasizes on subcortical deep gray matter and posterior limb internal capsule injury were utilized upon MRI assessment, using TW, T2W, and diffusion-weighted imaging (DWI) sequences. Cumulative MRI brain score was obtained and graded as none, mild, moderate, and severe brain injury. The MRI brain scoring was then correlated with patient's 2 years neurodevelopmental outcome using Fisher's Exact Test. Results: A total of 23 patients were eligible of which 19 term neonates were included. 13% of these neonates (n = 3) had mild MRI brain injury grading with 52.2% (n = 12) moderate and 34.8% (n = 8) severe. There was no significant correlation seen between MRI brain grading and developmental outcome at 2 years old (P > 0.05). Conclusion: There was no significant correlation between neonatal MRI brain injury grading and 2 years neurodevelopmental outcome. Nevertheless, the new MRI brain scoring by Trivedi et al. is reproducible and comprehensive as it involves various important brain structures, assessed from different MRI sequences.


How to cite this article:
Rusli ER, Ismail J, Wei WS, Ishak S, Jaafar R, Zaki FM. Neonatal hypoxic encephalopathy: Correlation between post-cooling brain MRI findings and 2 years neurodevelopmental outcome.Indian J Radiol Imaging 2019;29:350-355


How to cite this URL:
Rusli ER, Ismail J, Wei WS, Ishak S, Jaafar R, Zaki FM. Neonatal hypoxic encephalopathy: Correlation between post-cooling brain MRI findings and 2 years neurodevelopmental outcome. Indian J Radiol Imaging [serial online] 2019 [cited 2020 Jan 20 ];29:350-355
Available from: http://www.ijri.org/article.asp?issn=0971-3026;year=2019;volume=29;issue=4;spage=350;epage=355;aulast=Rusli;type=0