Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

: 2019  |  Volume : 29  |  Issue : 2  |  Page : 133--140

Gastrointestinal Stromal Tumor (GIST) from esophagus to anorectum – diagnosis, response evaluation and surveillance on computed tomography (CT) scan

Sushil N Panbude1, Suman K Ankathi1, Anant T Ramaswamy2, Avanish P Saklani3,  
1 Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India
2 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
3 Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Suman K Ankathi
Department of Radiodiagnosis, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra


Gastrointestinal stromal tumor (GIST) are the most common non epithelial tumor of the gastrointestinal (GI) tract. They arise from interstitial cells of Cajal present in the myenteric plexus. They can also arise outside the GI tract from mesentery, retro peritoneum and omentum. With the advent of new targeted molecular therapy c- tyrosine kinase inhibitor (Imatinib), it has become important to differentiate between response and pseudo-progression of the disease as response evaluation criteria for GIST are different from Response Evaluation Criteria in Solid Tumors (RECIST). Purpose of this pictorial essay is to enumerate the characteristic CT features of GIST, and discuss atypical features and response evaluation criteria.

How to cite this article:
Panbude SN, Ankathi SK, Ramaswamy AT, Saklani AP. Gastrointestinal Stromal Tumor (GIST) from esophagus to anorectum – diagnosis, response evaluation and surveillance on computed tomography (CT) scan.Indian J Radiol Imaging 2019;29:133-140

How to cite this URL:
Panbude SN, Ankathi SK, Ramaswamy AT, Saklani AP. Gastrointestinal Stromal Tumor (GIST) from esophagus to anorectum – diagnosis, response evaluation and surveillance on computed tomography (CT) scan. Indian J Radiol Imaging [serial online] 2019 [cited 2019 Jul 22 ];29:133-140
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Full Text


Gastrointestinal stromal tumors (GISTs) of Gastrointestinal (GI) tract are the most common non epithelial tumor as published in the western literature as well as in India.[1],[2],[3],[4] The GISTs are thought to arise from the interstitial cells of Cajal located in the myenteric plexus of GI tract and they are clearly different from other mesenchymal tumors like leiomyomas and leiomyosarcomas.[5] GISTs show mutations, most commonly in c-KIT gene which is seen only in GIST and not in other mesenchymal tumors [Figure 1]. c-KIT mutations result in activation of the KIT receptor tyrosine kinase that promotes growth and survival of tumor.[5],[6] However, up to 85-90% of GISTs have mutations in KIT and PDGFRA, whereas in the rest 10-15% these mutations are not seen and are referred to as wild type GISTs.[7],[8],[9] Some of these wild type GISTs are sporadic and others are associated with syndromes like neurofibromatosis, Carney-Stratakis syndrome and Carney triad.[10] In recent studies, it is shown that some of these wild type GISTs show mutations in BRAF V600E and succinate dehydrogenase (SDH) gene.[10],[11] Succinate dehydrogenase is the key enzyme in citric acid pathway. SDH deficient GISTs occur in younger patient, commonly gastric in origin and frequently metastasize to lymph nodes in addition to liver and peritoneum.[12] Definitive diagnosis of GIST is required because advanced GISTs are treated with new tyrosine kinase receptor inhibitor Imatinib mesylate, a selective adenosine triphosphate (ATP)–competitive inhibitor of KIT, BCR-ABL, and PDGFR-α and -β. Treatment with Imatinib in advanced GIST is associated with better response and improved survival.[13],[14],[15] Therefore, immunohistochemical confirmation with c-kit is vital for confirmation of diagnosis. GISTs are friable tumor and hence percutaneous biopsy may theoretically result in tumor rupture and dissemination, upstaging the disease. Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) is the alternative to obtain tissue diagnosis and it is safe and accurate procedure. For small resectable lesions, surgery is advised. However, for unresectable or metastatic disease or when treatment needs to be altered (if mass proved to be another neoplastic etiology), percutaneous ultrasound or CT guided biopsy can be performed.[16],[17]{Figure 1}

Primary management of small localized primary disease is surgical resection.[8] Locally advanced GIST may benefit from neoadjuvant Imatinib followed by surgery. For metastatic and recurrent GIST, Imatinib remains the mainstay of treatment.[8] For imatinib resistant GIST, sunitinib is a second line agent.[15] Sunitinib targets KIT and PDGFR-α, as well as the vascular endothelial cell growth factor receptor (VEGFR), fms-like tyrosine kinase 3 (Flt3) receptor, and RET receptor. Sorafenib and Regorafenib are the 3rd line of therapy for both Imatinib and Sunitinib resistant GISTs.[18],[19],[20]

With the advent of these new targeted therapies in GIST, it has now become important to evaluate response to these targeted therapies. After treatment with Imatinib, tumor size usually decreases. However, in early post treatment period, decrease in tumor size is minimal and in some cases it may increase due to development of hemorrhage, necrosis or myxoid degeneration, but there are dramatic changes in the tumor characteristic (like attenuation, nodularity and number of vessels). Because of these factors, the modified response evaluation criteria in solid tumors (mRECIST) cannot be used in response evaluation. Choi Criteria which uses a combination of tumor attenuation (≥15% decrease), and modified tumor size (≥10% decrease) is used to assess partial response.[21],[22] PET/CT can also be used in the response assessment of GIST treated with targeted molecular therapies and partial response status is redefined as a decrease in SUV at FDG PET (<70% from baseline or SUVmax <2.5).[21] However, PET/CT is costly and is not widely available. It cannot be used in GISTs which are initially PET negative.

This pictorial essay describes the CT characteristics of GIST at presentation, its post treatment evaluation and evaluation of disease recurrence during surveillance/follow-up.

GIST on ultrasound

Trans-abdominal ultrasonography is usually the first investigation for the palpable abdominal mass. On ultrasonography, GISTs are seen as heterogeneous masses due to necrosis, hemorrhage or cystic changes and are found in relation to the bowel.[23],[24] When large, it becomes difficult to identify the organ of origin. Liver metastases appear as hypoechoic lesions with respect to the liver parenchyma. Contrast enhanced ultrasound helps detect the viable portion of the tumor and hepatic metastasis. Endoscopic ultrasound is useful for small (<2 cm) and incidentally detected submucosal tumors and also facilitates endoscopic biopsy of such lesions.[23]

Computed tomography (CT) characteristics of GIST at presentation

CT plays an important role in the initial evaluation of GIST. Tumors are usually of varying density and show patchy enhancement on contrast enhanced CT scan [Figure 2]. Varying degrees of necrosis may be frequently demonstrated within the mass [Figure 2] and [Figure 3].{Figure 2}{Figure 3}

GIST can arise from any part of GI tract, from esophagus to anorectum as well as atypical GISTs arising from omentum, mesentery and retroperitoneum termed as Extra-gastrointestinal stromal tumors (EGIST).[25],[26],[27]


GISTs are uncommon tumors of the esophagus, most common esophageal tumor being leiomyoma. Leiomyomas tend to occur in younger age group with median age of presentation of 35 years and GISTs tend to occur in older age group with median age of 63 years.[28]

Esophageal GISTs more commonly arise in the lower esophagus followed by mid-esophagus. On computed tomography, they are seen as intraluminal (common), intramural or exophytic masses. They are hypodense masses and show mild enhancement. Necrosis and calcifications can be seen within.[29]

The differential diagnoses of esophageal GISTs depend on the predominant growth pattern. Small intraluminal GISTs can be confused with papilloma, adenoma, inflammatory polyp, fibrovascular polyp, and carcinoma which manifest as intraluminal polypoid masses. Large aggressive GISTs with extra serosal extension can mimic advanced stage carcinoma, malignant melanoma, lymphoma and leiomyosarcoma.[25]


Stomach is the most common location of GIST and most GISTs in stomach arise in the body followed by fundus and antrum.[25] Gastric GISTs can be endophytic, exophytic or mixed (dumbbell shaped) pattern, most common pattern is exophytic growth.[30] The extragastric extension can be seen in gastrohepatic ligament, gastrosplenic ligament, and lesser sac. Sometimes the large component of gastric GIST is extragastric and it becomes difficult to determine the organ of origin. In these cases, careful evaluation of stomach may show gastric wall thickening which suggests origin of tumor from stomach. Majority of cases (approximately 92%) show peripheral enhancement and this enhancing component represents viable tumor. Non enhancing component could be due to hemorrhage, necrosis or cystic changes. Minority of cases (approximately 8%) show homogeneous enhancement [Figure 4]. The cystic or necrotic areas may form cavities within and these cavities may communicate with the stomach resulting in air/air-fluid level/orally administered contrast in the tumor [Figure 5]. Calcification is unusual in GIST and is seen only in 3% of cases. Calcification can be mottled or extensive diffusely involving the tumor. CT also demonstrates the invasion of adjacent organ, liver, omental and peritoneal metastasis and ascites [Figure 6]. Metastatic lymphadenopathy is not a feature of GIST except for SDH deficient GISTs which can be associated with lymphadenopathy.[12],[25]{Figure 4}{Figure 5}{Figure 6}

The differential diagnoses of gastric GIST are adenocacinoma and lymphoma. Gastric adenocarcinoma often has perigastric, gastrohepatic and celiac adenopathy, not seen in GIST. Lymphoma has bulky abdominal adenopathy which may extend into the pelvis.

Small intestine

Small intestine is the second most common location of GIST after stomach. Tumor can arise from throughout the small intestine, i.e. duodenum, jejunum and ileum. Tumor extending into the bowel lumen may cause intestinal obstruction while those with extraserosal extension rarely cause intestinal obstruction.

CT depicts the mural, intraluminal and extraserosal component of small intestinal GIST. CT characteristics of small intestinal GISTs are very similar to gastric GIST. Most show heterogeneous post contrast enhancement [Figure 7]. Extraserosal extension into the adjacent small bowel, colon, ureter, urinary bladder or mesentery may occur. Metastasis to liver, omentum and peritoneum may occur and well evaluated by CT scan [Figure 7] and [Figure 8].[25]{Figure 7}{Figure 8}

The differentials are adenocarcinoma and lymphoma of small bowel. Neoplasms that originate primarily from the mesentery and secondarily involve the small intestine should also be included in the differential diagnosis. These tumors include mesenteric fibromatosis (desmoid tumor), inflammatory pseudotumor, sclerosing mesenteritis, and metastatic disease.

The adenocarcinoma of small intestine usually manifest as mural thickening with luminal narrowing and may be associated with intestinal obstruction which is uncommon in GIST. Lymphatic metastases can be seen in adenocarcinoma, not a feature of GIST. Small bowel lymphoma associated with luminal dilatation and extraserosal extension can be confused with GIST; however, lymphoma is associated with bulky adenopathy which is uncommon in GIST.[31]


Primary colonic GISTs are less common. The metastatic GIST to colon can involve the external surface of colon. Primary intramural tumors can involve the intraluminal or external aspect of the colon. Large tumors may have areas of hemorrhage, necrosis, cystic changes and calcification [Figure 3] and [Figure 9]. Circumferential growth with dilatation of the affected colon may also be seen.[25]{Figure 9}

CT appearances of colonic GISTs are similar to those of gastric or small intestinal GIST. Infiltration to adjacent organs may occur.

The radiologic differential diagnosis for colonic GISTs includes adenocarcinoma, lymphoma, metastatic melanoma, and leiomyosarcoma.


Anorectum is a common site of GISTs. Anorectal GIST can be seen as eccentric mural mass which can have extraserosal extension and may involve ischiorectal fossa, prostate and vagina [Figure 2]. Intraluminal extension is less common in anorectal GISTs [Figure 10]. CT shows heterogeneous post contrast enhancement of Anorectal GIST. Non enhancing areas with low attenuation on CT correspond to the necrotic/cystic areas. Calcification, usually, is not a feature of anorectal GIST. Metastatic adenopathy is uncommon.[32]{Figure 10}

The differential diagnoses of anorectal GISTs include rectal adenocarcinoma and squamous cell carcinoma, melanoma, lymphoma, carcinoid, leiomyoma and leiomyosarcoma.

Extra-gastrointestinal GIST (EGIST)

Extra-gastrointestinal GISTs may arise in the omentum, mesentery or retroperitoneum and are unrelated to the gastrointestinal tract.[27] EGISTs, though reported in literature, are rare. They share histological and immunohistochemical features with gastrointestinal GIST. They show staining with KIT, a marker of interstitial cells of Cajal which are normally present in the GI tract.[33] The reason why these cells, which are normally present in the gut wall, reach the omentum, mesentery and retroperitoneum and then develop into a tumor is not yet clear. Most, if not all, primarily arise from the gut and have extensive extramural component which then lose contact with gut wall.[34],[35] Another hypothesis is that this tumor may arise from the multipotent mesenchymal stem cells.[36]

Primary EGIST may be homogeneous hypodense masses showing homogeneous post contrast enhancement or may have cystic, hemorrhagic and necrotic component giving it complex appearance. Solid portion shows contrast enhancement [Figure 11]A and [Figure 11]B. The differential diagnoses of primary EGISTs are leiomyosarcoma, fibrosarcoma, liposarcoma and malignant fibrous histiocytoma. Mesenteric fibromatosis are usually homogeneous without any hemorrhage, necrosis or cystic changes within.[25]{Figure 11}

GIST from the primary gastrointestinal tract origin may metastasize to the peritoneum. In these cases, there are usually multiple masses throughout the peritoneal cavity which is uncommon in primary peritoneal GIST [Figure 8]B. The differential diagnoses are peritoneal carcinomatosis, lymphomatosis and leiomyomatosis peritonealis disseminata.[25]

Metastatic GIST

About 50% of GISTs have metastasis at presentation. GISTs metastasize usually to the liver and peritoneum via hematogenous spread and peritoneal seeding, most common site is liver.[37] Liver metastases are usually multiple, can involve both lobes and can have variegated attenuation. They are hypoattenuating on plain scan and shows heterogeneous post contrast enhancement. Central area is more hypodense than periphery and is due to cystic/necrotic changes. Peripheral enhancing part is solid viable tumor. Sometimes they show early post contrast enhancement in arterial phase and become isodense to rest of the liver parenchyma in delayed phase scan. Hence, triphasic CT scan is essential to look for liver metastases. Sometimes heterogeneous appearance with cystic lesion, fluid-fluid levels or multilocular appearance is seen and is due to intratumoral hemorrhage, necrosis or calcification. Often tumor vessels are seen within the tumors [Figure 6], [Figure 7], [Figure 8].[37],[38] Peritoneal metastases can occur when there is tumor extension beyond serosa or can occur after percutaneous biopsy. Peritoneal metastases are in the form of peritoneal or omental nodule or less commonly there can be omental caking. Peritoneal metastasis appear like primary tumor on CT. They can be hyper-enhancing solid masses or can be heterogeneous due to cystic/necrotic changes, bleeding or calcifications [Figure 8]B. Tumor vessels can be seen within the tumors.[38] Ascites is rare and is more attributable to the treatment. Lymph node metastasis is rare though reported in the literature and lymph node metastases are more common in SDH deficient GIST.[12],[38] Lymph node metastasis have imaging feature similar to that of primary tumor. Lung, bone, adrenal and cutaneous metastases are rare though reported in literature and commonly seen in association with liver and peritoneal metastases. Bone metastases are usually lytic and are commonly seen in spine and pelvic bones. Lung metastases are seen as soft tissue nodules in association with liver/peritoneal metastases. Adrenal metastases are rare and when present they have attenuation characteristics similar to the primary tumor [Figure 12].[38],[39]{Figure 12}

Response assessment in GIST

Surgery is mainstay of treatment in the management of GIST. However, targeted therapy with Imatinib and other TKI inhibitors has been widely used in management of GIST. In large tumors, neoadjuvant Imatinib is used to downsize the tumor to avoid morbid surgery and preserving the organs.[40] Post-operative, adjuvant therapy with Imatinib is given for up to 3 years.[41] In metastatic GIST, Imatinib is mainstay of therapy.[42]

Computed Tomography (CT) scan is routinely used to monitor response in primary or metastatic GIST. After treatment with Imatinib, there is decrease in tumor size, attenuation and tumor vessels [Figure 13]. Decrease in tumor size after Imatinib may take several months before satisfying traditional response criteria such as mRECIST. In contrast, on contrast enhanced CT scan, there is dramatically decrease in tumor attenuation value, measured in Hounsfield Units (HU) and this decrease in attenuation is seen within one month. This decrease in tumor attenuation is due to development of myxoid degeneration and occasionally due to hemorrhage and necrosis.[37] Paradoxically, tumor may enlarge after treatment and is due to development of myxoid changes or intratumoral hemorrhage.[37] Accordingly, alternate tumor response criteria incorporating changes in tumor attenuation along with size reduction were proposed by Choi et al. According to the Choi criteria, a 15% decrease in CT attenuation or 10% decrease in unidimensional size indicates response in contrast to 30% decrease in unidimensional size as per RECIST.[22],[43]{Figure 13}

PET/CT can also be used in the response assessment of GIST treated with targeted molecular therapies. However, PET/CT is costly and is not widely available. It cannot be used in GISTs which are initially PET negative. On PET/CT, partial response status is defined as a decrease in SUV at FDG PET (<70% from baseline or SUVmax < 2.5) [Figure 14].[21]{Figure 14}

Imatinib is known to cause fluid retention, diarrhea, nausea, abdominal pain and rash, in patients undergoing treatment for GIST. The most common adverse effect is fluid retention which may manifest as extensive subcutaneous edema, ascites, pleural and pericardial effusion. New onset of ascites in follow up CT scan may be mistakenly interpreted as peritoneal disease and wrongly labeled as progressive disease.[37]

Patients who develop primary or secondary resistance to Imatinib are treated with second line Sunitinib and third line Sorafenib/Regorafenib.[19],[20],[44] It is not known if dramatic density changes as seen with Imatinib also occur with Sunitinib and Regorafenib. However, in few studies, Choi criteria was not useful for response assessment after treatment with Sunitinib and Regorafenib and RECIST 1.1 was useful in evaluating progression free survival.[45],[46],[47]


Although surgery is mainstay of treatment, recurrences occur in most patients even after complete resection with negative margins. Once the tumor is resected or has responded to treatment, it is important to detect recurrence or disease progression as early as possible for the benefit of patient.

Recurrences typically occur first in liver or peritoneum, so these sites along with site of primary tumor should be carefully evaluated to look for recurrence. Traditional criteria for disease progression are increase in tumor size, development of new lesion and appearance of metastasis and these are also of value in monitoring patients with GIST. In previously treated GIST with hypoattenuating cystic lesion, increase in size or density and development of new enhancing intratumoral nodule referred to as nodule within mass is also consistent with disease recurrence or progression, regardless of change in size of tumor.[37],[48]


Gastrointestinal stromal tumor (GIST) is the most common non epithelial tumor of the gastrointestinal (GI) tract. With advancement in treatment modalities in GIST, it is important to diagnose and accurately stage GIST for optimal benefit of patient. With new targeted molecular therapy, response assessment is important in which case modified response evaluation criteria in solid tumors (mRECIST) may not be helpful after Imatinib treatment but is useful for response evaluation after second and third line Sunitinib and Sorafenib/Regorafenib treatment respectively. We also have discussed about the surveillance in treated GIST.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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