Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

CARDIAC RADIOLOGY
Year
: 2019  |  Volume : 29  |  Issue : 1  |  Page : 33--39

Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study


Ishan Kumar1, Priyanka Aggarwal2, Vineeta Gupta2, Ashish Verma1, Suwen Kumar3, Ram C Shukla1 
1 Department of Radiodiagnosis, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
2 Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
3 Department of Cardiology, Queen's Medical Center, Honolulu, Hawaii, USA

Correspondence Address:
Dr. Ashish Verma
Department of Radiodiagnosis, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, Uttar Pradesh
India

Background: Cardiac iron deposition in transfusion-dependent thalassemia patients is patchy in distribution. Purpose: The purpose of this study is to assess the correlation between T2* matrices of membranous interventricular septum (MIVS) and T2* values of muscular interventricular septum (IVS) on magnetic resonance imaging (MRI) and to evaluate the relationship of myocardial T2* at these two locations with MRI-estimated liver iron concentrations (LIC) and electrocardiographic (ECG) parameters. Material and Methods: MRI of heart and liver was performed in 16 consecutive pediatric patients of transfusion-dependent thalassemia major to calculate liver iron concentration and T2* time of membranous and muscular IVS. ECG parameters of these patients were charted and correlated with MRI parameters. Results: No significant correlation between T2* values of muscular IVS and MIVS was observed. Mean T2* of MIVS (9.8 ms) was significantly lower than that of muscular IVS (26.9 ms). T2* of MIVS correlated strongly with LIC where as a weak correlation was observed between T2* of IVS and LIC. Significantly higher mean QTc (corrected QT interval) value (439.86 ms) was seen in patients with T2* IVS <20 ms. Conclusion: Addition of T2* analysis of MIVS to the existing MRI protocol, consisting of muscular IVS analysis, may offer a more sensitive estimation of cardiac iron overload.


How to cite this article:
Kumar I, Aggarwal P, Gupta V, Verma A, Kumar S, Shukla RC. Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study.Indian J Radiol Imaging 2019;29:33-39


How to cite this URL:
Kumar I, Aggarwal P, Gupta V, Verma A, Kumar S, Shukla RC. Cardiac T2* magnetic resonance analysis of membranous interventricular septum in assessment of cardiac iron overload in pediatric thalassemia patients: A pilot study. Indian J Radiol Imaging [serial online] 2019 [cited 2019 Sep 19 ];29:33-39
Available from: http://www.ijri.org/article.asp?issn=0971-3026;year=2019;volume=29;issue=1;spage=33;epage=39;aulast=Kumar;type=0