Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

VASCULAR AND INTERVENTIONAL RADIOLOGY MINI SYMPOSIA
Year
: 2013  |  Volume : 23  |  Issue : 2  |  Page : 126--133

Endovascular treatment of hepatocellular carcinoma with drug eluting microparticles (DC-Beads): CT evaluation of response to the treatment


Emanuele Boatta1, Mario Corona1, Alessandro Cannavale1, Fabrizio Fanelli1, Carlo Cirelli1, Lorenzo de Medici2 
1 Department of Radiological Sciences, Vascular and Interventional Radiology Unit, University of Rome "Sapienza", Rome, Italy
2 Department of Radiology, Guarnieri Hospital, Raoul Gueze Foundation, Rome, Italy

Correspondence Address:
Alessandro Cannavale
Department of Radiological Sciences, University of Rome źDQ╗SapienzaźDQ╗, 324 Viale Regina Elena - 00161, Rome
Italy

Background and Study Aims: Our aim was to assess the efficacy and tolerability of drug-eluting beads-transarterial chemoembolization (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC), evaluating the response to the treatment after 1, 6, 12, and 24 months with multidetector computed tomography (MDCT) comparing European Association for the study of the Liver (EASL) and modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. Materials and Methods: We enrolled 154 patients with uni- or multifocal HCC who underwent a DEB-TACE. A total of 278 HCC nodules were treated. CT follow-up was performed at 1, 6, 12, and 24 months after the procedure according to the EASL and RECIST criteria evaluating overall target and target nodule response. We also analyzed the shrinking of nodules in relation to response to treatment. Results: A total of 278 nodules of HCC underwent TACE by using DC-Beads: At 24, months complete response was similar for EASL and RECIST criteria (112 vs. 121 nodules) with optimal accordance between methods and readers with k = 0.9. Partial Response resulted significantly different among the two methods within the first month, otherwise was similar after 24-month follow-up. Similar results in both methods were found for nodules classified as Stable Disease (P > 0.05). Progressive Disease results were similar in both the groups according to both the classification criteria without any significant difference (P > 0.05). Conclusion: Our study confirmed that EASL and mRECIST criteria are both effective methods for patient follow-up, however with some technical differences.


How to cite this article:
Boatta E, Corona M, Cannavale A, Fanelli F, Cirelli C, de Medici L. Endovascular treatment of hepatocellular carcinoma with drug eluting microparticles (DC-Beads): CT evaluation of response to the treatment.Indian J Radiol Imaging 2013;23:126-133


How to cite this URL:
Boatta E, Corona M, Cannavale A, Fanelli F, Cirelli C, de Medici L. Endovascular treatment of hepatocellular carcinoma with drug eluting microparticles (DC-Beads): CT evaluation of response to the treatment. Indian J Radiol Imaging [serial online] 2013 [cited 2019 Nov 16 ];23:126-133
Available from: http://www.ijri.org/article.asp?issn=0971-3026;year=2013;volume=23;issue=2;spage=126;epage=133;aulast=Boatta;type=0