Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

BREAST RADIOLOGY
Year
: 2013  |  Volume : 23  |  Issue : 1  |  Page : 19--25

Role of quantitative pharmacokinetic parameter (transfer constant: Ktrans ) in the characterization of breast lesions on MRI


Jena Amarnath, Taneja Sangeeta, Shashi Bhushan Mehta 
 Department of MRI, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India

Correspondence Address:
Taneja Sangeeta
Department of MRI, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi - 110 085
India

Background: The semi-quantitative analysis of the time-intensity curves in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has a limited specificity due to overlapping enhancement patterns after gadolinium administration. With the advances in technology and faster sequences, imaging of the entire breast can be done in a few seconds, which allows measuring the transit of contrast (transfer constant: K trans ) through the vascular bed at capillary level that reflects quantitative measure of porosity/permeability of tumor vessels. Aim: Our study aims to evaluate the pharmacokinetic parameter K trans for enhancing breast lesions and correlate it with histopathology, and assess accuracy, sensitivity, and specificity of this parameter in discriminating benign and malignant breast lesions. Materials and Methods: One hundred and fifty-one women with 216 histologically proved enhancing breast lesions underwent high temporal resolution DCE-MRI for the early dynamic analysis for calculation of pharmacokinetic parameters (K trans ) using standard two compartment model. The calculated values of K trans were correlated with histopathology to calculate the sensitivity, specificity, and accuracy. Results: Receiver operating characteristic (ROC) curve analysis revealed a mean K trans value of 0.56, which reliably distinguished benign and malignant breast lesions with a sensitivity of 91.1% and specificity of 90.3% with an overall accuracy of 89.3%. The area under curve (AUC) was 0.907. Conclusion: K trans is a reliable quantitative parameter for characterizing benign and malignant lesions in routine DCE-MRI of breasts.


How to cite this article:
Amarnath J, Sangeeta T, Mehta SB. Role of quantitative pharmacokinetic parameter (transfer constant: Ktrans ) in the characterization of breast lesions on MRI.Indian J Radiol Imaging 2013;23:19-25


How to cite this URL:
Amarnath J, Sangeeta T, Mehta SB. Role of quantitative pharmacokinetic parameter (transfer constant: Ktrans ) in the characterization of breast lesions on MRI. Indian J Radiol Imaging [serial online] 2013 [cited 2019 Nov 14 ];23:19-25
Available from: http://www.ijri.org/article.asp?issn=0971-3026;year=2013;volume=23;issue=1;spage=19;epage=25;aulast=Amarnath;type=0