Indian Journal of Radiology and Imaging Indian Journal of Radiology and Imaging

NEURORADIOLOGY
Year
: 2008  |  Volume : 18  |  Issue : 3  |  Page : 210--217

Clinical applications of functional MRI in epilepsy


Chandrasekharan Kesavadas, Bejoy Thomas 
 Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, India

Correspondence Address:
Chandrasekharan Kesavadas
Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011
India

The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team«SQ»s decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed.


How to cite this article:
Kesavadas C, Thomas B. Clinical applications of functional MRI in epilepsy.Indian J Radiol Imaging 2008;18:210-217


How to cite this URL:
Kesavadas C, Thomas B. Clinical applications of functional MRI in epilepsy. Indian J Radiol Imaging [serial online] 2008 [cited 2020 Feb 26 ];18:210-217
Available from: http://www.ijri.org/article.asp?issn=0971-3026;year=2008;volume=18;issue=3;spage=210;epage=217;aulast=Kesavadas;type=0