Indian Journal of Radiology Indian Journal of Radiology  

   Login   | Users online: 851

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size     


Year : 2019  |  Volume : 29  |  Issue : 2  |  Page : 195-200
Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads

1 Department of Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University, Cairo, Egypt
2 Department of Radiology, University of Missouri, USA
3 Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Dr. Ayman Nada
Department of Radiology, University of Missouri
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijri.IJRI_383_18

Rights and Permissions

Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of residual malignant tumor of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with drug-eluting beads (DEBs). Subjects and Methods: Pre-contrast T1, T2, dynamic contrast–enhanced, and respiratory-triggered DW-MRI (b factor 0, 400, and 800 s/mm2) were obtained in 60 patients with HCC who underwent tran-sarterial hepatic chemoembolization with DEBs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the DW imaging images. Apparent diffusion coefficients (ADCs) were calculated searching for the optimal cut-off value using the receiver operating characteristic (ROC) curve. Results: DW-MRI had a sensitivity of 77.1%, a specificity of 60.7%, a PPV of 71.05%, and a NPV of 68%. The difference between the malignant and benign groups' ADC variables was statistically significant (P < 0.003). The ROC curve showed that the area under the curve is C = 0.718 with SE = 0.069 and 95% confidence interval from 0.548 to 0.852. Conclusion: In our study, we demonstrated that diffusion MRI has limited diagnostic value in the assessment of viable tumor tissue after TACE with DEBs in cases of HCC.

Print this article     Email this article

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
  Citation Manager
 Access Statistics
  Reader Comments
  Email Alert *
  Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded69    
    Comments [Add]    

Recommend this journal