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PAEDIATRIC IMAGING Table of Contents   
Year : 2018  |  Volume : 28  |  Issue : 1  |  Page : 107-110
Brown fat necrosis with calcifications in the newborn: Risk factors, radiographic findings, and clinical course


Department of Radiology and Imaging Sciences, Children's Healthcare of Atlanta and Emory University, 1405 Clifton Road NE, Atlanta, 30322, Georgia

Correspondence Address:
Dr. Eleza T Golden
Northside Radiology Associates 5775 Glendridge Dr #525 Atlanta
Georgia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijri.IJRI_67_17

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Objective: To describe the radiographic appearance of subclinical calcified brown fat necrosis and the associated clinical and laboratory findings. Materials and Methods: Picture Archiving and Communications Sytem (PACS) was searched using keywords “soft tissue calcification” and “chest.” The clinical record was searched for prior cardiac surgery, bypass, Extracorporeal Membrane Oxygentation (ECMO) and prostaglandin use. Age when calcifications were first detected, location, resolution, and associated laboratory abnormalities were recorded. Results: Nine patients were identified. None had skin lesions. All patients had congenital heart disease and had experienced cardiac/respiratory arrest and/or severe hypotension 1–6 weeks before soft tissue calcifications occurred. Calcifications resolved by 9 weeks to 5 months in 3 patients. The remaining were either deceased or lacked follow-up imaging. Renal ultrasound was performed in all but 1 patient. Nephrocalcinosis was only seen in 1 patient. Conclusion: Brown fat necrosis is subclinical, diagnosed on plain film, and likely self-limited. It occurs in term and preterm infants who have undergone significant systemic stress and carries a poor prognosis.


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