|Year : 2016 | Volume
| Issue : 4 | Page : 423-428
|Abdominal lymphatic malformation: Spectrum of imaging findings
Anupam Lal1, Pankaj Gupta1, Manphool Singhal1, Saroj K Sinha2, Sadhana Lal2, Surinder Rana2, Niranjan Khandelwal1
1 Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
2 Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Click here for correspondence address and email
|Date of Web Publication||14-Dec-2016|
| Abstract|| |
Lymphatic malformations are congenital vascular malformations with lymphatic differentiation. Although the most common locations for lymphatic malformation are the neck and axilla, they can occur at several locations in the body including the abdomen. The abdominal location is rather rare and accounts for approximately 5% of all lymphatic malformation. Abdominal lymphatic malformation can arise from mesentery, omentum, gastrointestinal tract, and retroperitoneum. Clinical presentation includes an abdominal lump, vague abdominal discomfort, and secondary complications including intestinal obstruction, volvulus, ischemia, and bleeding. There is a broad spectrum of radiological manifestation. In the present review, we discuss the imaging appearance of abdominal lymphatic malformation. The diagnosis of lymphatic malformation in our series was based on the histopathological examination (in cases who underwent surgery) and fine needle aspiration cytology.
Keywords: Abdomen; lymphatic malformation; mesentery; retroperitoneum
|How to cite this article:|
Lal A, Gupta P, Singhal M, Sinha SK, Lal S, Rana S, Khandelwal N. Abdominal lymphatic malformation: Spectrum of imaging findings. Indian J Radiol Imaging 2016;26:423-8
|How to cite this URL:|
Lal A, Gupta P, Singhal M, Sinha SK, Lal S, Rana S, Khandelwal N. Abdominal lymphatic malformation: Spectrum of imaging findings. Indian J Radiol Imaging [serial online] 2016 [cited 2017 Jul 22];26:423-8. Available from: http://www.ijri.org/text.asp?2016/26/4/423/195777
| Introduction|| |
Lymphatic malformations are a form of congenital vascular malformations. The usual location is head and neck. Abdominal lymphatic malformation are rare, comprising only 5% of all lymphatic malformations. Within the abdominal cavity, they occur in mesentry, retroperitoneum, solid organs (liver, spleen, pancreas) and gastrointestinal tract. Complications including gastrointestinal obstruction, hemorrhage and volvulus mandate treatment in all cases. Surgery remains the treatment of choice. The less invasive form of treatment including per cutaneous sclerotherapy have a greater recurrence rate. In this review we present the imaging spectrum of abdominal lymphatic malformations.
| Embryological Basis|| |
The lymphatic system of the body is derived between 12th and 16th weeks of gestation from endothelial channels located in the neck, root of the mesentery, and the femoral and sciatic vein bifurcation. Sequestration of the lymphatic channels leads to the development of lymphatic malformations. Continued growth of these lesions represents both the accumulation of fluid and the proliferation of pre-existing spaces.
Grossly, lymphatic malformations appear as thin-walled cystic lesions with a smooth external surface. Cut surface may reveal macroscopic or microscopic cysts. The fluid in the cysts may be serous, hemorrhagic, or chylous. Microscopically, the cysts are lined by flattened endothelial cells. The cyst fluid is eosinophilic. The stroma shows collagen fibres, lymphocytes, and occasional lymphoid aggregates.
Both male and female predominance has been reported in abdominal lymphatic malformation. The majority of abdominal lymphatic malformations are diagnosed in children. The clinical presentation is highly variable depending on the size and exact location of the lesion. They are symptomatic in as many as 88%. Presenting features are abdominal pain, abdominal distension, nausea, vomiting, constipation, diarrhea, and abdominal mass.
Mesenteric lymphatic malformation
The mesentery is the most common site for abdominal lymphatic malformations. Mesenteric lymphatic malformations are known to produce serious complications including hemorrhage, intestinal ischemia, obstruction, and volvulus. On ultrasound, lymphatic malformations appear as multilocular cystic masses [Figure 1]A. They are often anechoic but may also contain echogenic debris. Less commonly, the lesions may appear as predominantly solid [Figure 1]B. On computed tomography, the fluid component of the lymphatic malformation is homogeneous and shows low attenuation values [Figure 2]A. Following administration of intravenous contrast, enhancement of the cyst wall and septa is seen [Figure 2]B. Less common computed tomography (CT) manifestation includes negative attenuation values due to the presence of predominantly chylous fluid. Calcification and hemorrhage are other uncommon imaging findings on CT [Figure 2]C.,, Magnetic resonance imaging (MRI) signal intensity parallels that of the fluid appearing hypointense on T1-weighted images and markedly hyperintense on T2-weighted images [Figrue 3]A. Heterogeneous signal intensity is seen in the presence of hemorrhage and infection [Figure 3]B. In addition to suggesting a diagnosis of lymphatic malformation, imaging provides information regardingthe extent of lesions, aiding in accurate surgical planning.
|Figure 1 (A and B): Gray scale ultrasound (US) image (A) showing mesenteric lymphatic malformation as multiple anechoic cystic spaces (arrows). US image (B) showing the mesenteric lymphatic malformation as a solid echogenic lesion (arrows). The diagnosis in later case (B) was confirmed at surgery|
Click here to view
|Figure 2 (A-C): Axial contrast-enhanced computed tomography (CECT) image (A) showing mesenteric lymphatic malformation as a low attenuation lesion (arrows). Coronal reformatted CECT image (B) showing a mesenteric lymphatic malformation with peripheral thin contrast enhancement (arrow). Axial non-contrast CT image (C) showing punctate calcific focus (short arrow) within the lymphatic malformation (arrow)|
Click here to view
|Figure 3 (A and B): Axial fat-suppressed T2-weighted magnetic resonance (MR) image (A) showing markedly hyperintense lesion (arrows). Coronal T2-weighted MR image (B) showing a heterogeneous lesion with fluid component (arrows) and hemorrhage (short arrows)|
Click here to view
Percutaneous biopsy is not recommended in typical cases as there is low cellularity and negative yield in most cases. In addition, in rare cases of cystic malignancy, there is a theoretical risk of needle tract seeding. Fine needle aspiration cytology (FNAC) is a less invasive technique compared to biopsy. It allows confident diagnosis of lymphatic malformation, especially in patients with atypical presentation, age, and location. It is a safe alternative to more cumbersome and time-consuming surgical modalities of diagnosis. The differential diagnoses of mesenteric lymphatic malformations include uncomplicated ascites (free of septations) and fluid-containing masses in the abdomen [Figure 4]., Ascites is characterized by the lack of septations or displacement of bowel loops. Moreover, ascitic fluid tends to gravitate to the dependent sites including paracolic gutters, Morison's pouch, and pelvis. Mesothelial cysts, enteric duplication cysts, and pseudocysts mimic mesenteric lymphatic malformations closely, and preoperative imaging diagnosis may be impossible. Several other conditions simulating mesenteric lymphatic malformations have been described. These include malignant gynecological lesions (ovarian malignancies) and abdominal tuberculosis. Overall, the features that support lymphatic malformation on imaging include the absence of solid areas, fine septa, low-level septal vascularity, and absence of significant mass effect on adjacent structures. MRI and ultrasound are better at discriminating the cystic nature of the lesions. The role of chemical shift MRI to differentiate mesenteric lymphatic malformations from other cystic masses has also been described. As described above, in certain cases with atypical clinical features, FNAC may aid in diagnosis.
|Figure 4: Axial non-contrast CT image showing lymphatic malformation as a hypodense lesion (arrow) mimicking ascites. Shorter arrow points toward urinary bladder. Aspiration cytology of the fluid supported the diagnosis of lymphatic malformation|
Click here to view
Retroperitoneal lymphatic malformations
Retroperitoneal lymphatic malformations are extremely rare and comprise less than 1% of the abdominal lymphatic malformations., They usually present in older children and adults. Clinically, they present as palpable abdominal masses, abdominal pain, intestinal or ureteric obstruction, and hematuria. Asymptomatic lesions may be detected incidentally during imaging evaluation for unrelated indications. Histologically, the retroperitoneal lesions are almost always of cystic variety. The imaging features are similar to those of cystic mesenteric lymphatic malformations [Figure 5]A and [Figure 5]B. An important feature on imaging that differentiates these lesions from other pathologies is the insinuating nature crossing multiple compartments. Retroperitoneal cystic teratoma is an important differential diagnosis.
|Figure 5 (A and B): Axial T2-weighted magnetic resonance (MR) image (A) showing lymphatic malformation in the anterior pararenal space along with fluid component (arrows) and septations (short arrows). Parasagittal T1-weighted postcontrast image (B) shows the lesion to be hypointense (arrows) with enhancing septum (short arrow)|
Click here to view
Gastrointestinal tract lymphatic malformations
Gastrointestinal tract (GIT) is an infrequent location for abdominal lymphatic malformations. These intramural lesions are frequently asymptomatic and detected incidentally on radiologic studies or at endoscopy. The lesions appear as smoothly marginated intramural masses on barium studies and deform with compression. Homogeneous low-attenuation is seen at CT [Figure 6]A and [Figure 6]B. Endoscopic ultrasound confirms the cystic nature of these lesions.
|Figure 6 (A and B): Coronal (A) and sagittal (B) reformatted images showing duodenal lymphatic malformation as an ill-defined hypodense lesion along the second and third parts of duodenum (arrows). The diagnosis was confirmed following surgery|
Click here to view
Hepatic lymphatic malformations
Primary hepatic lymphatic malformations are extremely uncommon. Hepatic lymphatic malformations may be seen in isolation or as a part of systemic lymphatic malformation or hepatosplenic lymphatic malformation. Isolated hepatic lesions are seen in relatively older children and adults compared to systemic or hepatosplenic lymphatic malformation that usually present during infancy, or early childhood. Hepatic lymphatic malformations present as single or multiple cysts [Figure 7]. The imaging features are similar to lymphatic malformations elsewhere in the body. Hyperechoic lesions resembling hemangiomas are also seen infrequently. This appearance is related to small size lymphatic spaces separated by abundant fibrous tissue. The differential diagnosis includes other hepatic cysts including polycystic liver disease, hydatid cysts, and cystic tumors including cystic metastasis and mesenchymal hamartoma.
|Figure 7: Axial computed tomography image shows multiple well-defined hypodense lesions (arrows) in the liver as a part of hepatic lymphatic malformation. Also note left moderate pleural effusion. The diagnosis of lymphatic malformation was supported by aspiration cytology|
Click here to view
Splenic lymphatic malformations
Splenic lymphatic malformations usually occur in subcapsular locations [Figure 8]A. This location reflects the anatomic distribution of lymphatics draining splenic parenchyma. Less common sites for splenic lymphatic malformations include intraparenchymal location presenting as well defined lesions [Figure 8]B or global splenic enlargement. There are no distinct imaging features of splenic lymphatic malformations. Lesions closely resembling splenic lymphatic malformations include true splenic cysts, pseudocysts, infective lesions including pyogenic abscesses and hydatidcysts, infarction, peliosis, and neoplastic lesions including hemangioma, lymphoma, and cystic metastasis.
|Figure 8 (A and B): Axial gray scale ultrasound image (A) shows a splenic subcapsular lymphatic malformation (arrows). Short arrows in (A) outline the spleen. Sagittal contrast-enhanced computed tomography image (B) shows splenic lymphatic malformation as multiple focal lesions (arrows). Also note punctate calcification (short arrow). The diagnosis in this case was confirmed by fine needle aspiration cytology|
Click here to view
Lymphatic malformations of extrahepatic biliary tree
This is a rare site for abdominal lymphatic malformations. These lesions usually arise from the gallbladder and are characterized by multilocular cystic appearance compressing the gallbladder lumen.
Renal lymphatic malformations
Renal lymphatic malformations are rare lesions and usually present as focal lesions [Figure 9]A, [Figure 9]B, [Figure 9]C, [Figure 9]D. Less commonly, these present as diffuse lymphatic malformations or renal lymphangectasia[Figure 10]. They appear as cystic lesions (uni or multilocular) on imaging. Rare cases of solid appearing lymphatic malformations have been reported. The proposed mechanism for such appearance is the numerous interfaces between microcysts of the lymphatic malformation. Differential diagnosis on imaging in adults includes hydronephrosis, benign renal cysts, renal abscess, and cystic renal tumors including multilocular cystic nephroma and renal cell carcinoma. Multilocular cystic nephroma is the chief differential diagnosis in children.
|Figure 9 (A-D): Gray scale ultrasound image shows anechoic structures within the renal sinus (arrows) mimicking hydronephrosis. Sagittal contrast-enhanced computed tomography image (B) of the same patient shows the lesion as hypodense tubular structures (arrows) that were seen distinct from the pelvicalyceal system in the excretory phase (short arrows, C). Also note a well-defined liver lesion with peripheral hyperdense rim suggestive of a liver hydatid. Coronal T2-weighted magnetic resonance image (D) shows the abnormality as hyperintense channels in the right renal sinus (arrows)|
Click here to view
|Figure 10 (A and B): Axial contrast-enhanced computed tomography (CECT) (A) image shows bilateral diffuse perinephric lymphatic malformations (arrows).Coronal CT image (B) shows right perinephric lymphatic malformation (arrows)|
Click here to view
Pancreatic lymphatic malformations
Lymphatic malformations are said to be of primary pancreatic origin only when they are located within the pancreatic parenchyma, are attached to the pancreas by a pedicle, or have a broad area of contact with the pancreas [Figure 11]. The most common cystic lesion in relation to the pancreas is a pseudocyst. Other differential considerations are cystic neoplasms including cystic neuroendocrine neoplasms, mucinous or serous neoplasms, solid pseudopapillary epithelial neoplasms, and intraductal papillary mucinous neoplasms. Definite imaging diagnosis is difficult as these lesions closely resemble lymphatic malformations.
|Figure 11: Axial contrast-enhanced computed tomographyimage shows a well-defined hyperdense lesion (arrow) having a broad area of contact with the distal pancreatic body and tail.Fine needle aspiration cytologyof the lesion led to a diagnosis of lymphatic malformation|
Click here to view
| Treatment|| |
Treatment is recommended in all (even asymptomatic) cases as the incidence of several complications such as bleeding, infection, bowel obstruction, and volvulus tends to increase with time as the lesion size increases., Complete resection has conventionally been advocated as the treatment of choice for all types of abdominal lymphatic malformations. For all sites combined, a recurrence rate of 40% after incomplete resection and 17% after macroscopically complete resection was shown. Moreover, recurrence is more common in larger lesions. Sclerotherapy is the less invasive form of treatment. A variety of sclerosing agents, including ethanol, sodium tetradecylsulfate, bleomycin, doxycycline, and OK-432 (picibanil), has been shown to be effective in the treatment of macrocystic lesions. Variable recurrence has been reported following sclerotherapy, with up to 100% in some series., The rate of recurrence depends on the lesion location, size, and complexity.,
| Conclusion|| |
Abdominal lymphatic malformations, although rare, should be kept in the differential diagnosis of cystic lesions occurring in the various abdominal compartment and abdominal viscera, both solid and GIT. Clinical presentation is extremely variable. Preoperative diagnosis may be facilitated by FNAC. Definite treatment is required in most cases due to the fear of complications. Surgery is the mainstay of treatment. Other forms of treatment may have a higher recurrence rate.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Wilson SR, Bohrer S, Losada R, Price AP. Retroperitoneal lymphangioma: An unusual location and presentation. J Pediatr Surg 2006;41:603-5.
Takiff H, Calabria R, Yin L, Stabile, BE. Mesenteric cysts and intra-abdominal cystic lymphangiomas. Arch Surg 1985;120:1266-9.
Weiss SW, Goldblum JR. Benign tumors and tumor-like lesions of blood vessels. In: Weiss SW, Goldblum JR, editors. Enzinger and Weiss's soft tissue tumors. 4th
ed. St Louis, Mo: Mosby; 2001. p. 837-90.
Ros PR, Olmsted WW, Moser RPJr, Dachman AH, Hjermstad BH, Sobin LH. Mesenteric and omental cysts: Histologic classification with imaging correlation. Radiology 1987;164:327-32.
Levy AD, Cantisani V, Miettinen M. Abdominal lymphangiomas: Imaging features with pathologic correlation. Am J Roentgenol 2004;182:1485-91.
Wani I. Mesenteric lymphangioma in adult: A case series with a review of the literature. Dig Dis Sci 2009;54:2758-62.
Kim JK, Ahn HJ, Kim KR, Cho KS. Renal lymphangioma manifested as a solid mass on ultra-sonography and computed tomography. J Ultrasound Med 2002;21:203-6.
Ko SF, Ng SH, Shieh CS, Lin JW, Huang CC, Lee TY. Mesenteric cystic lymphangioma with myxoid degeneration: Unusual CT and MR manifestations. Pediatr Radiol 1995;25:525-7.
de Perrot M, Rostan O, Morel P, Le Coultre C. Abdominal lymphangioma in adults and children. Br J Surg 1998;85:395-7.
MaaJ, JaigirdirA, ChoSJ, Corvera CU. Giant mesenteric cystic lymphangioma presenting with abdominal pain and masquerading as a gynecologic malignancy. Rare Tumors 2009;1:e48.
Lugo-Olivieri CH, Taylor GA. CT differentiation of large abdominal lymphangioma from ascites. Pediatr Radiol 1993;23:129-30.
Ayyappan AP, Jhaveri KS, Haider MA. Radiological assessment of mesenteric and retroperitoneal cysts in adults: Is there a role for chemical shift MRI? Clin Imaging 2011;35:127-32.
Davidson AJ, Hartman DS. Lymphangioma of the retroperitoneum: CT and sonographic characteristic. Radiology 1990;175:507-10.
Muramori K, Zaizen Y, Noguchi S. Abdominal lymphangioma in children: Report of three cases. Surg Today 2009;39:414-7.
Mimura T, Kuramoto S, Hashimoto M, Yamasaki K, Kobayashi K, Kobayashi M, et al
. Un-roofing for lymphangioma of the large intestine: A new approach to endoscopic treatment. Gastrointest Endosc 1997;46:259-63.
O'Sullivan DA, Torres VE, de Groen PC, Batts KP, King BF, Vockley J. Hepatic lymphangiomatosis mimicking polycystic liver disease. Mayo Clin Proc 1998;73:1188-92.
Wadsworth DT, Newman B, Abramson SJ, Carpenter BL, Lorenzo RL. Splenic lymphangiomatosis in children. Radiology 1997;202:173-6.
Choi JY, Kim MJ, Chung JJ, Park SI, Lee JT, Yoo H, et al
. Gallbladder lymphangioma: MR findings. Abdom Imaging 2002;27:54-7.
Levine E. Lymphangioma presenting as a small renal mass during childhood. Urol Radiol 1992;14:155-8.
Paal E, Thompson LD, Heffess CS. A clinico-pathologic and immunohistochemical study of ten pancreatic lymphangiomas and a review of the literature. Cancer 1998;82:2150-8.
Hancock BJ, St-Vil D, Luks FI, Di Lorenzo M, Blanchard H. Complications of lymphangiomas in children. J Pediatr Surg 1992;27:220-4.
Kosir MA, Sonnino RE, Gauderer MW. Pediatric abdominal lymphangiomas: Aplea for early recognition. J Pediatr Surg 1991;26:1309-13.
Stein M, Hsu R, Schneider P, Ruebner B, Mina Y. Alcohol ablation of a mesenteric lymphangioma. J VascInterv Radiol 2000;11:247-50.
Burrows PE, Mitri RK, Alomari A, Padua HM, Lord DJ, Sylvia MB, et al
. Percutaneous sclerotherapy of lymphatic malformations with doxycycline. Lymphat Res Biol 2008;6:209-16.
Molitch HI, Unger EC, Witte CL, van Sonnenberg E. Percutaneous sclerotherapy of lymphangiomas. Radiology 1995;194:343-7.
Shiels WE II, Kang DR, Murakami JW, Hogan MJ, Wiet GJ. Percutaneous treatment of lymphatic malformations. Otolaryngol Head Neck Surg 2009;141:219-24.
Algahtani A, Nguyen LT, Flageole H, Shaw K, Laberge JM. 25 Years' experience with lymphangiomas in children. J Pediatr Surg 1999;34:1164-8.
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10], [Figure 11]
| Article Access Statistics|
| Viewed||1298 |
| Printed||24 |
| Emailed||0 |
| PDF Downloaded||295 |
| Comments ||[Add] |