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Year : 2016  |  Volume : 26  |  Issue : 3  |  Page : 328-331
Multiparametric 3T MRI evaluation of hereditary spastic paraplegia: A case report


Department of Radiology, IPGMER and SSKM Hospital, Kolkata, India

Correspondence Address:
Archana Singh
Department of Radiology, IPGMER and SSKM Hospital, Kolkata
India
Ruchira Das
Department of Radiology, IPGMER and SSKM Hospital, Kolkata
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-3026.190413

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Hereditary spastic paraplegia (HSP) is a rare heterogeneous group of familial neurodegenerative disorders characterized by degeneration of the corticospinal tracts and posterior column of the spinal cord. Previously described radiological findings included nonspecific brain abnormalities such as brain atrophy and white matter lesions, as well as atrophy of the corpus callosum and spinal cord. Magnetic resonance spectroscopy may reveal reduced concentrations of normal brain metabolites and elevated levels of myoinositol. Diffusion tensor imaging shows increased mean diffusivity and reduced fractional anisotropy in the periventricular white matter, which is compatible with damaged myelinated axons. We present here two cases of HSP in a single family with typical imaging findings.


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