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ABDOMINAL RADIOLOGY  
Year : 2014  |  Volume : 24  |  Issue : 1  |  Page : 87-90
Cobb's collar occurring in two brothers in a family: A rare entity revisited


1 Department of Medicine, Calcutta National Medical College and Hospital, Kolkata, West Bengal, India
2 Department of Medicine, Medical College and Hospital, Kolkata, West Bengal, India
3 Department of Radiology, Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India

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Date of Web Publication16-Apr-2014
 

   Abstract 

Most urethral strictures arise from iatrogenic, traumatic, or inflammatory causes. We report the familial occurrence of a congenital bulbar urethral stricture in two brothers. Retrograde and voiding cystourethrography was performed. A Cobb's collar was diagnosed after radiological and endoscopic evaluation in both cases and was successfully managed with urethroplasty. Cobb's collar is a rarely recognized cause of a membranous stricture of bulbar urethra that can lead to several urinary problems. In cases of adolescent and young adults presenting with symptoms of progressive urinary obstruction and enuresis with or without urinary tract infection, Cobb's collar can be seen as a minor constriction in the bulbar urethra, but is not frequently symptomatic, and the familial occurrence of such a stricture is even rarer.

Keywords: Bulbar urethra; Cobb′s collar; congenital strictures; cystourethrography; urethroplasty

How to cite this article:
Pal P, Ray S, Talukdar A, Sonthalia N, Chakraborty S. Cobb's collar occurring in two brothers in a family: A rare entity revisited. Indian J Radiol Imaging 2014;24:87-90

How to cite this URL:
Pal P, Ray S, Talukdar A, Sonthalia N, Chakraborty S. Cobb's collar occurring in two brothers in a family: A rare entity revisited. Indian J Radiol Imaging [serial online] 2014 [cited 2020 Jun 5];24:87-90. Available from: http://www.ijri.org/text.asp?2014/24/1/87/130714

   Introduction Top


Cobb's collar [1] or Moormann's ring [2] is a largely underestimated cause of male bulbar urethral strictures. It can potentially lead to acute urinary retention, upper urinary tract dilatations, enuresis, infection, poor streaming, and hematuria. Embryologically, this focal bulbar urethral stricture develops due to failure of canalization of the cloacal membrane during fetal development. [3] In Cobb's collar, the site of obstruction is more distal than that seen with posterior urethral valves (PUV). [4] A prompt diagnosis with minimally invasive treatment may avoid upper and lower tract deterioration in these patients. We present two cases of congenital bulbar urethral obstruction (Cobb's collar) occurring in brothers. The anatomy, embryology, and clinical features are discussed in order to turn the spotlight on to this rare disease.


   Case Reports Top


Case 1

A 30-year-old man presented with a long history of a worsening urinary stream and a sense of incomplete voiding and straining at micturition. He had two episodes of near retention before admission. There was no history of traumatic injury, instrumentation of the urethra, or sexually transmitted disease. Abdominal and genitourinary examination revealed an enlarged and distended urinary bladder with normal-looking external genitalia.

Renal function tests and urine routine examination were within normal limits, and urine culture showed no growth. USG of the abdomen revealed bilateral mild hydronephrosis [Figure 1]a, presence of hydroureters, a dilated prostatic urethra, and a thick-walled over-distended bladder. Pre-void (1972 ml), first (957 ml) and second post-void (790 ml) residual volumes were significantly raised [Figure 1]b. Urodynamic study could not be performed as catheterization failed due to the tightness of the urethral stricture. Subsequent retrograde urethrogram (RGU) showed a 3-cm stricture in the bulbar urethra [Figure 2]a. Micturating cystourethrogram (MCU) using the suprapubic route showed a narrowing in the proximal bulbar urethra, without reflux into the collecting system [Figure 2]b. Endoscopic evaluation revealed a bulbar-obstructing membrane. The urinary bladder wall was mildly trabeculated. A Cobb's collar was diagnosed. Suprapubic catheterization (SPC) with visual internal urethrotomy (VIU) was performed and the patient was discharged. Later, he was readmitted for a voiding trial and Teflon dilatation. In view of the persistent urinary problems, the patient was planned for buccal mucosal onlay urethroplasty. The postoperative course was uneventful, and the patient voids without complaints at 6 months follow-up.
Figure 1 (A, B): (A) Bilateral mild hydronephrosis (B) significant post-void urine residue (Case 1)

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Figure 2 (A, B): (A) Retrograde urethrogram demonstrating a narrowing in the proximal bulbar urethra, (B) micturating cystourethrogram (MCU) showed a narrowing in the proximal bulbar urethra (white ring) (Case 1)

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Case 2

The first case's 25-year-old younger brother also complained of poor urinary stream and straining at micturition. He had no history of urethral trauma, instrumentation, or infection. Physical examination of the abdomen and genitalia was unremarkable. Renal function tests and urine routine examination were within normal limits. USG showed mild hydronephrotic changes, hydroureters, and a thickened bladder wall, with significant post-voiding residue. RGU was performed which showed a short segment stricture in the bulbar urethra [Figure 3]. A Cobb's collar was diagnosed and successfully managed with VIU. The patient is asymptomatic at 6 months follow-up, with normal serial USG evaluations.
Figure 3: Retrograde urethrogram showing bulbar urethral stricture (Case 2)

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   Discussion Top


The proximal prostatic and membranous part of the male urethra is formed by endodermal tissues and the penile part is formed from the phallic portion of the urogenital sinus. Congenital idiopathic urethral stricture may result from incomplete rupture of the cloacal membrane at the junction of membranous and bulbar urethra which may correspond to submeatal stenosis in girls. [3]

Cobb et al. (1968) were the first to draw attention to the entity of congenital stricture of the bulbar urethra. [1] They analyzed 52 cases of proximal bulbar urethral obstruction in male patients for a 3-year period. Twenty-six out of 52 patients were boys under 16 years of age; of these 26 boys, 16 had a trabeculated bladder, 15 showed a dilated prostatic fossa, whereas 6 had a secondary hydroureter, and the most frequently referred symptoms were enuresis, urinary tract infection, hematuria, and failure to thrive. Three different types of Cobb's collar have been identified. All these forms of obstruction are located just below the external sphincter [5] [Figure 4].
Figure 4: Sagittal section through prostate and urethra showing the area of Cobb's collar. It can appear either as a ridge of tissue (Cobb's collar I) or as a definite stricture in the area described (Cobb's collar II) or even as a very tight pinhole opening (Cobb's collar III). P, prostate; S, external sphincter; C, Cobb's collar

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Such strictures of the bulbar urethra had been underestimated for many years until the first half of the 1990s when Dewan et al.[6] and later Nonomura et al.[7] redefined and classified the bulbar urethral narrowing by reviewing video-recorded cystoscopies as well as radiological pictures in the patients. Both studies showed that the majority of patients were below 1 year of age with a large number showing vesicoureteral reflux (VUR), with no history of urethral trauma, catheterization, or instrumentation. VUR in association with clinical findings and endoscopic findings of vestigial remnants at the level of bulbar urethra indicates that this narrowing has a congenital onset. Presentation at a later age, as occurred in our cases, may represent delayed presentation of a congenital stricture. Their response to treatment is clearly different from that of the under 1 year olds, since majority require buccal mucosal onlay urethroplasty or scrotal or penile island flap urethroplasty. The more common causes of congenital urethral stricture are different types of posterior urethral obstruction, which was originally described as PUV (three types) by Young et al., but these obstructions were found to be diaphragmatic obstruction as suggested by Parkkulainen on endoscopic studies. [8] Congenital attachment of the verumontanum to the anterior wall of the posterior urethra is the embryologic forerunner to the congenital obstruction of the posterior urethra. Congenital obstructing posterior urethral membrane (COPUM), first described by Dewan et al., is a new terminology of the same. More distal bulbar urethral abnormality without folds running up to the verumontanum is likely to be a remnant of urogenital diaphragm, commonly known as Cobb's collar. [9]

Banks et al., [10] in their series of 12 pediatric patients with bulbar or posterior urethral stenosis, identified a sort of bimodal distribution of age at presentation, with 50% of patients presenting during the first year of life, whereas 5 of the remaining 6 patients presented after the age of 11. This late presentation may represent a delayed presentation of a congenital stricture, or may be due to a forgotten urethral trauma or asymptomatic inflammation. Clinical presentation may be variable and, often, may be related to the use of blind urethral catheterization in these patients. Chronic urinary retention and bilateral hydronephrosis may be a presenting feature in some patients, as in our case. [10],[11] These adult patients may also complain of poor ejaculation. [5] Late presentation of Cobb's collar (caused by a persistence of urogenital membrane) can be differentiated from acquired stricture by the absence of the characteristic folds between COPUM anomalies and verumontanum. [12]

Pediatric urologists continue to debate whether the Cobb's collar or Moormann's ring represents a true urethral stricture or not. Some consider Cobb's collar to be a benign physiological narrowing of the bulbar urethra, easily passable with a cystoscope, although Cobb describes a series of bulbar strictures in a pediatric population in his original paper. So, although rare, Cobb's collar has to be considered in the differential diagnosis of progressive urinary flow obstruction and enuresis, especially in pediatric and adolescent patients where acquired traumatic, iatrogenic, or inflammatory strictures are more common. Radiologically indistinguishable dysfunctional voiding due to involuntary contraction of urethral sphincter or pelvic floor muscles and Hinman syndrome (functional non-neurogenic bladder) are also important differential diagnoses to be considered. Contrast-enhanced conventional radiological studies can identify this anomaly and also be helpful in postoperative follow-up of this entity which can be easily treatable by minimally invasive endoscopic corrective surgery. [12] Late-onset cases may need urethroplasty. Familial occurrence of Cobb's collar is exceedingly rare and only few cases are reported in the literature, indicating that this entity may have a familial basis. [13] Screening for family members is an important part of managing these patients. In the absence of traditional risk factors, careful family history should be taken. If the biopsy of the stricture and histological examination shows a normal urethral mucosa and the absence of any inflammation or fibrosis, then Cobb's collar becomes the likely diagnosis.


   Conclusion Top


From the limited data available and from the cases reported here, it is clear that urethral strictures often present with an unknown etiology. Although extremely uncommon, in cases of adolescent or pediatric patients presenting with symptoms of progressive urinary obstruction and enuresis with or without urinary tract infection and/or hematuria, a bulbar urethral obstruction such as Cobb's collar should be considered.


   Acknowledgment Top


The authors thank Dr. Dilip Karmakar (Professor and Head, Department of Urology, Calcutta National Medical College and Hospital, Kolkata) for performing the repair operation in our patient.

 
   References Top

1.Cobb BG, Wolf JA Jr, Ansell JS. Congenital stricture of the proximal urethral bulb. J Urol 1968;99:629-31.  Back to cited text no. 1
[PUBMED]    
2.Moormann JG. Congenital bulbar urethral stenosis as a cause of diseases of the urogenital junction. Urologe A 1972;11:157-60.  Back to cited text no. 2
[PUBMED]    
3.Sadler TW. Urogenital System in Langman's Medical Embryology. 11 th ed. Philadelphia, PA: Walters Kluwer/Lippincott Williams and Wilkins; 2010. p. 235-40.  Back to cited text no. 3
    
4.Manzoni C, Valentini AL. Posterior urethral valves. Rays 2002;27:131-4.  Back to cited text no. 4
    
5.Cranston D, Davies AH, Smith JC. Cobb's collar--a forgotten entity. Br J Urol 1990;66:294-6.  Back to cited text no. 5
    
6.Dewan PA, Pillay S, Kaye K. Correlation of the endoscopic and radiological anatomy of congenital obstruction of the posterior urethra and the external sphincter. Br J Urol 1997;79:790-6.  Back to cited text no. 6
    
7.Nonomura K, Kanno T, Kakizaki H, Koyama T, Yamashita T, Koyanagi T. Impact of congenital narrowing of the bulbar urethra (Cobb's collar) and its transurethral incision in children. Eur Urol 1999;36:144-8; discussion 149.  Back to cited text no. 7
[PUBMED]    
8.Parkkulainen KV. Posterior urethral obstruction: Valvular or diaphragmatic? Endoscopic diagnosis and treatment. Birth Defects Orig Artic Ser 1977;13:63-74.  Back to cited text no. 8
[PUBMED]    
9.Dewan PA, Keenan RJ, Morris LL, Le Quesne GW. Congenital urethral obstruction: Cobb's collar or prolapsed congenital obstructive posterior urethral membrane (COPUM). Br J Urol 1994;73:91-5.  Back to cited text no. 9
    
10.Banks FC, Griffin SJ, Steinbrecher HA, Malone PS. Aetiology and treatment of symptomatic idiopathic urethral strictures in children. J Pediatr Urol 2009;5:215-8.  Back to cited text no. 10
    
11.Adorisio O, Bassani F, Silveri M. Cobb's collar: A rare cause of urinary retention. BMJ Case Rep 2013 Jan 22;2013. pii: bcr2012008137. doi: 10.1136/bcr-2012-008137.  Back to cited text no. 11
    
12.Dewan PA, Goh DG. Variable expression of the congenital obstructive posterior urethral membrane. Urology 1995;45:507-9.  Back to cited text no. 12
    
13.Aragona F, Maio G, Oliva G, Calabrò A, Ostardo E, Artibani W. Familial occurrence of congenital stricture of bulbar urethra. Urol Int 1991;46:112-3.  Back to cited text no. 13
    

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Correspondence Address:
Sayantan Ray
Department of Medicine, Calcutta National Medical College, 24, Gorachand Road, Kolkata - 700 014, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-3026.130714

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    Abstract
   Introduction
   Case Reports
   Discussion
   Conclusion
   Acknowledgment
    References
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