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FMRI-MINI SYMPOSIA Table of Contents   
Year : 2014  |  Volume : 24  |  Issue : 1  |  Page : 22-36
Clinical utility of BOLD fMRI in preoperative work-up of epilepsy


Department of 3T fMRI, SRL Diagnostics and Jankharia Imaging, Mumbai, Maharashtra, India

Correspondence Address:
Karthik Ganesan
Department of 3T fMRI, SRL Diagnostics and Jankharia Imaging, Piramal Tower Annexe, Gr. Floor, G.K. Marg, Next to A to Z Industrial Estate, Off Worli Naka, Lower Parel, Mumbai - 400 013, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-3026.130688

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Surgical techniques have emerged as a viable therapeutic option in patients with drug refractory epilepsy. Pre-surgical evaluation of epilepsy requires a comprehensive, multiparametric, and multimodal approach for precise localization of the epileptogenic focus. Various non-invasive techniques are available at the disposal of the treating physician to detect the epileptogenic focus, which include electroencephalography (EEG), video-EEG, magnetic resonance imaging (MRI), functional MRI including blood oxygen level dependent (BOLD) techniques, single photon emission tomography (SPECT), and 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Currently, non-invasive high-resolution MR imaging techniques play pivotal roles in the preoperative detection of the seizure focus, and represent the foundation for successful epilepsy surgery. BOLD functional magnetic resonance imaging (fMRI) maps allow for precise localization of the eloquent cortex in relation to the seizure focus. This review article focuses on the clinical utility of BOLD (fMRI) in the pre-surgical work-up of epilepsy patients.


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