Indian Journal of Radiology Indian Journal of Radiology  

   Login   | Users online: 1137

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size     

 

NEURORADIOLOGY Table of Contents   
Year : 2007  |  Volume : 17  |  Issue : 3  |  Page : 156-158
Images: Bilateral agenesis of the internal carotid arteries - MRI and MR angiography


Department of Radiodiagnosis, Rural Medical College, Loni - 413 736, Rahata, Ahmednagar, India

Click here for correspondence address and email
 

How to cite this article:
Desai S M, Kashyape R S. Images: Bilateral agenesis of the internal carotid arteries - MRI and MR angiography. Indian J Radiol Imaging 2007;17:156-8

How to cite this URL:
Desai S M, Kashyape R S. Images: Bilateral agenesis of the internal carotid arteries - MRI and MR angiography. Indian J Radiol Imaging [serial online] 2007 [cited 2020 Feb 24];17:156-8. Available from: http://www.ijri.org/text.asp?2007/17/3/156/33630
A 55-years-old woman came with sudden onset left hemiparesis for 12h, following an episode of convulsions. On admission, the power was grade 2/5 in the left upper and lower limbs. An MRI brain was performed. The MRI showed hyperintense areas in the right high frontal and parietal lobes on T2W images [Figure - 1], with restricted diffusion on diffusion-weighted (DW) images [Figure - 2], representing acute non-hemorrhagic infarcts. In addition, the axial spin-echo (SE) T1W and T2W [Figure - 3] images revealed absence of the normal flow voids of the internal carotid arteries (ICAs) in the region of the carotid canals in the skull base. The expected regions of the carotid canals were filled with fibro-fatty tissue.

The 3D time-of-flight (TOF) MRI angiography (MRA) images [Figure - 4],[Figure - 5] demonstrated prominent posterior cerebral arteries supplying both the anterior circulations through the posterior communicating arteries. The axial raw data (source images) [Figure - 6] confirmed the absence of flow signals in the expected location of the ICAs on either side. No other vascular abnormality was seen in the form of aneurysm or focal stenosis.

Subsequently, the patient was managed with anticoagulant therapy, to which she responded favorably. No complications were encountered during her hospital stay till her discharge after nine days. She left with mild residual weakness in the left upper and lower limbs.


   Discussion Top


Absence of the internal carotid artery (ICA) is a rare congenital anomaly, [1] which may be the result of an acquired disease (common), congenital hypoplasia (uncommon) or congenital aplasia (rare). This is more commonly seen unilaterally. [2],[3] Most reported cases of bilateral absence have been recorded prior to 1980. [4] Previous reports have been largely based on catheter angiography. [5] In 1954, the first case of ICA agenesis at cerebral angiography was reported by Verbiest. [1] Earlier case reports relied on dissection studies. [2]

Lie [6] defined agenesis as complete failure of an organ to develop, aplasia as lack of development (but its precursor did exist at one time) and hypoplasia as incomplete development of the organ. Although an exact cause of these developmental anomalies has not been established, all three variations are thought to represent the sequelae from an insult to the developing embryo. [4] To date, an explanation for bilateral absence has not been rendered. [4] Evaluation of the skull base for the presence or absence of the carotid canal may be required for distinguishing aplasia from agenesis, as presence of the ICA (or its precursor) is a prerequisite for development of the carotid canal at five to six weeks of gestation. [6] Therefore, demonstrating an absence of the carotid canal with skull base CT will confirm the diagnosis of agenesis. [7]

Several case reports have discussed the MRI and MRA findings in unilateral aplasia or hypoplasia of the ICA, including children. [2] Bilateral absence of the ICA is a rare abnormality. [2] Kidooka et al believed the MRA assessment in their case was equivalent to that provided by catheter angiography. [3] Anderson's case report [2] also suggests that MRA is able to successfully demonstrate ICA absence and common collateralization in a noninvasive fashion.

Usually, patients with this anomaly are asymptomatic; some may have symptoms related to cerebrovascular insufficiency, compression by enlarged intracranial collateral vessels or complications associated with cerebral aneurysms. [8]

The estimated prevalence of cerebral aneurysms in the general population is 2-4%, but the reported prevalence of aneurysms in association with absence of ICA is 24% to 34%. [1] Recognition of this anomaly becomes important in thromboembolic disease, as emboli in one cerebral hemisphere may be explained by atherosclerotic disease in the contralateral common carotid artery (CCA) or vertebro-basilar system. [1]

Lie [6] described six pathways of collateral circulation in association with absence of the ICA. Others have simplified Lie's original classification of collateral circulation in absent ICAs into three main types: collateral flow through the circle of Willis ( most frequent and also seen in the present case ); collateral flow via persistent fetal circulation and reconstitution of the ICA through skull base collaterals from the ECA. [1]

The MRA in this case demonstrated supply to the anterior circulation via enlarged posterior communicating arteries, the most commonly seen collateral arrangement. [9]

 
   References Top

1.Given CA, Huang-Hellinger F, Baker MD, Chepuri NB, Morris PP. Congenital absence of the internal carotid artery: Case reports and review of the collateral circulation. AJNR Am J Neuroradiol 2001;22:1953-9.   Back to cited text no. 1    
2.Anderson DW. Bilateral absence of the internal carotid artery: MR angiography and ultrasound findings. Br J Radiol 2005;78:569-72.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Kidooka M, Okada T, Handa J. Agenesis of the internal carotid artery - report of a case combined with arachnoid cyst in a child. No To Shinkei 1992;44:371-5.  Back to cited text no. 3  [PUBMED]  
4.Lie TA. Congenital anomalies of the carotid arteries. Excerpta Medica: Amsterdam; 1968. p. 35-51.  Back to cited text no. 4    
5.Teal JS, Naheedy MH, Hasso AN. Total agenesis of the internal carotid artery. Am J Neuroradiol 1980;1:435-42.  Back to cited text no. 5    
6.Quint DJ, Boulos RS, Spera TD. Congenital absence of the cervical and petrous internal carotid artery with intercavernous anastomosis. Am J Neuroradiol 1989;10:435-9.  Back to cited text no. 6  [PUBMED]  
7.Florio F, Balzano S, Nardella M, Strizzi V, Cammisa M, Bozzini V, et al . Congenital absence of the internal carotid artery. Cardiovasc Intervent Radiol 1999;22:74-8.  Back to cited text no. 7  [PUBMED]  [FULLTEXT]
8.Cali RL, Berg R, Rama K. Bilateral internal carotid artery agenesis: a case study and review of the literature. Surgery 1993;113:227-33.  Back to cited text no. 8  [PUBMED]  
9.Servo A. Agenesis of the left internal carotid artery associated with an aneurysm on the right carotid siphon. Case report. J Neurosurg 1977;46:677-80.  Back to cited text no. 9    

Top
Correspondence Address:
R S Kashyape
Kashyape Hospital, Trimbak Naka, Old Agra Road, Nashik - 422 02, Maharashatra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-3026.33630

Rights and Permissions


    Figures

  [Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6]

This article has been cited by
1 Bilateral congenital absence of internal carotid arteries in a woman with dementia: A case report
Viglianesi, A. and Messina, M. and Chiaramonte, R. and Chiaramonte, I. and Vecchio, I. and Pero, G.
Neuroradiology Journal. 2010; 23(1): 7-10
[Pubmed]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed4237    
    Printed96    
    Emailed1    
    PDF Downloaded330    
    Comments [Add]    
    Cited by others 1    

Recommend this journal