Indian Journal of Radiology Indian Journal of Radiology  

   Login   | Users online: 1447

Home Bookmark this page Print this page Email this page Small font sizeDefault font size Increase font size     

 

GENITOURINARY IMAGING Table of Contents   
Year : 2005  |  Volume : 15  |  Issue : 2  |  Page : 195-198
Case report : Xanthogranulomatous pyelonephritis - an unusual variety


Department of Radiology & Imaging, Smt S.C.L. Hospital Saraspur, Smt N.H.L. Municipal Medical college, Ahmedabad-380006, India

Click here for correspondence address and email
 

Keywords: Xanthogranulomatous pyelonephritis, USG, CT, MRI

How to cite this article:
Dani R D, Gandhi V S, Prajapati H J, Shah P, Raval H, Rathod G D. Case report : Xanthogranulomatous pyelonephritis - an unusual variety. Indian J Radiol Imaging 2005;15:195-8

How to cite this URL:
Dani R D, Gandhi V S, Prajapati H J, Shah P, Raval H, Rathod G D. Case report : Xanthogranulomatous pyelonephritis - an unusual variety. Indian J Radiol Imaging [serial online] 2005 [cited 2019 Jun 24];15:195-8. Available from: http://www.ijri.org/text.asp?2005/15/2/195/28800

   Introduction Top


Xanthogranulomatous pyelonephritis is an uncommon inflammatory process characterized by focal or diffuse replacement of the renal parenchyma by yellow lipid contained macrophages [1].

Here, we would like to report a case of xanthogranulomatous pyelonephritis in which amorphous amount of fat was present surrounding the staghorn calculus in left renal sinus.


   Case report Top


A 30 years old woman patient came to hospital with complains of left sided flank pain, low grade fever and weight loss during last three months.

On clinical examination, lump was palpable in left lumber region.

Radiograph KUB was taken, showed large staghorn calculus in left renal area and other small multiple calculi noted inferolateral to the stag horn calculus. [Figure - 1]

Sonography performed with 3.5 MHz curvilinear probe showed huge pyonephrotic left kidney occupying whole left hypochodrium and lumber region with gross dilatation of upper and mid calyces with thinned out cortex with internal echoes in it. Large staghorn calculus noted in left renal sinus with marked echogenic area noted surrounding the calculus and renal sinus was not dilated. Other multiple small calculi were noted in left lower calyx. [Figure - 2]

IVU was done, showed nonfunctioning left kidney with staghorn and other small calculi in left renal area.

Plain CT Scan of abdomen was performed. CT Scan showed hydronephrotic huge left kidney with gross dilatation of upper and middle calyces. Large dense staghorn calculus was present in left renal sinus with large areas of low attenuation (negative attenuation value -85 to -100 HU) noted surrounding it. Left renal sinus was contracted. Multiple small calculi noted in left lower calyx with fat density noted at corticomedullary junction in lower part. Posterior perirenal fat was involved by infection. [Figure - 3]

From above findings diagnosis of Xanthogranulomatous pyelonephritis was considered.

Subsequently MRI of abdomen was performed, which confirmed the findings of CT Scan. MRI showed upper pole of left kidney was not separately seen from left dome of diaphragm. [Figure - 4],[Figure - 5],[Figure - 6]

During operation, left kidney was found to be adherent to left dome of diaphragm, lateral part of transverse colon and left upper psoas muscle. Left kidney was removed except adherent portion. Calculi were removed and large amount of fat was present surrounding the staghorn calculus. [Figure - 7]

Histopathological report was xanthoganulogranulomatous pyelonephritis. Microscopically appearance was typical of xanthogranulomatous pyelonephritis, showed abundance of lipid-laden macrophages, lymphocytes and plasma cells. [Figure - 8]


   Discussion Top


Xanthogranulomaous pyelonephritis is a chronic renal infection that in its most common form leads to scarred contracted renal pelvis, dilated calyces and diffuse infiltration of the renal parenchyma by plasma cells and lipid laden macrophages, which may form multiple yellow-colored masses. The term xanthogranulomatous describes the yellow color imparted to the renal parenchyma and inflammatory masses by the high lipid content of macrophages. Calculus in the pelvis of xanthogranulomatous kidneys occur in over 75 percent of cases. Calculus usually assumes staghorn shape and is composed of struvite. The dilated calyces, whose walls are thickened by inflammatory are filled with pus. Extension of the inflammatory process into psoas muscle and perirenal and pararenal spaces occurs frequently. Parenchymal calcification is uncommon [2].

There is marked female preponderance and 10 percent patients are diabetic [3]. There is accumulation of lipid laden macrophages (xanthoma cells) and a granulomatous infiltrate because of failure of local immunity [4]. Signs and symptoms include abdominal and flank pain, low grade fever, weight loss, and malaise. Many patients have no lower urinary tract symptoms. A renal mass may be palpable. Anemia, leukocytosis, pyuria and albuminuria may be present. Bacteria are cultured from the urine in approximately two third of patients.  Proteus mirabilis Scientific Name Search  and  Escherichia More Details coli are the organisms most likely to be found [2]. A history of urolithiasis is present in about 35 percent of the patients and hepatic dysfunction may be present in 50 percent of the patients [5].

In 85 percent the entire kidney is involved but disease may be focal. Computed tomography is very useful, because the findings on sonography and urography are nonspecific. On CT, xanthogranulomatous pyelonephritis is associated with: (a) a large central calculus, often a staghorn; (b) enlargement of the kidney (or of a segment); (c) poor or no excretion of contrast into the collecting system; and (d) multiple focal low-attenuation(-10 to +30 HU) masses scattered throughout the involved portions of the kidney. The low attenuation collection represents dilated, debris-filled calyces and xanthoma collections. The collection themselves do not enhance, and there is no excretion of contrast, but there is bright enhancement of the rims of the collections, because of inflammatory hypervascularity. Perinephric extension occurs in about 14 percent and is well shown on CT, fistulae may develop and gas may rarely seen. Some variation occur: the kidney may be small, and calculi may be absent, making it difficult to distinguish xanthogranulomatous pyelonephritis from other infections or neoplasm [6]. CT is particularly valuable in that it not only demonstrates characteristic renal findings, but also shows the extent of inflammation and extent into adjacent tissues. This will aid in surgical planning in choosing an approach that will provide adequate exposure and facilitate patient care [7].

In diffuse form of xanthogranulomatous pyelonephritis, USG demonstrates multifocal enlargement of the kidney. The dominant findings reflects the markedly dilated calyces that are filled with products of inflammation and are seen as multiple, uniformly aligned hypo echoic structures with an internal pattern of fine echoes. The frequently present pelvic calculus causes a highly reflective image with acoustic shadowing. Parenchymal xanthogranulomatous masses cause focal zones of echogenicity [2].

 
   References Top

1.Grainger RG, Allison DJ, Diagnostic Radiology; textbook of medical imaging, Vol. II, 4th ed. : Churchill Livingstone, 1551:1563.  Back to cited text no. 1    
2.Davidson AJ, Hartman DS, Radiology of the Kidney and Urinary Tract, 2nd ed.: W.B.Saunders, 309-313.  Back to cited text no. 2    
3.Sutton D, Textbook of Radiology and Imaging, Vol. II, 7th ed.: Churchill Livingstone, 944.  Back to cited text no. 3    
4.Hayes WS, Hartman DS, Sesterhenn IA. From the archives of the AFIP. Xanthogranulomatous pyelonephritis. Radiographics 1991; 11:485-498.  Back to cited text no. 4    
5.Tanagho EA, McAninch JW, Smith's General Urology, 16th ed.: Lange Medical Books/MaGraw-Hill, 213-214.  Back to cited text no. 5    
6.Lee Joseph KT, Sagel SS, Stanley RJ et al, Computer Body Tomography, Vol.II, 3rd ed.: Lippincott Raven, 1150-1151.  Back to cited text no. 6    
7.James Eastham, Thomas Ahlering, Eila Skinner, Xanthogranulomatous pyelonephritis: Clinical findings and surgical considerations. Urology March 1994; 43:295-299.  Back to cited text no. 7    

Top
Correspondence Address:
R D Dani
83, yogeshwarnagar society, Opp, Anjali Theater, Near Dharnidhar Society, Bhatta, Paldi, Ahmedabad-380007, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-3026.28800

Rights and Permissions


    Figures

[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5], [Figure - 6], [Figure - 7], [Figure - 8]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  


    Introduction
    Case report
    Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed5381    
    Printed94    
    Emailed2    
    PDF Downloaded447    
    Comments [Add]    

Recommend this journal